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Whey Protein Versus Whey Protein Hydrolyzate for the Protection of Azoxymethane and Dextran Sodium Sulfate Induced Colonic Tumors in Rats

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dc.contributor.authorYALÇIN, AHMET SUHA
dc.contributor.authorsAttaallah, Wafi; Yilmaz, Ayse Mine; Erdogan, Nusret; Yalcin, A. Suha; Aktan, A. Ozdemir
dc.date.accessioned2022-03-12T18:06:11Z
dc.date.available2022-03-12T18:06:11Z
dc.date.issued2012
dc.description.abstractRecent studies have shown that whey protein has many useful effects including its anti-cancer effect. In this study we have compared the protective effect of dietary whey protein with whey protein hydrolyzate against azoxymethane and dextran sodium sulfate induced colon cancer in rats. We used a rat model of the colon cancer induced by administration of azoxymethane followed by repeated dextran sodium sulfate ingestion which causes multiple tumor development. Colon tissues were analyzed histologically in addition to biochemical analyses performed by measuring lipid peroxidation, protein oxidation and glutathione levels in both of colon and liver tissues of rats after sacrification. Macroscopic and microscopic tumors were identified in all groups that received azoxymethane followed by repeated dextran sodium sulfate. Group fed with whey protein hydrolyzate showed significantly less macroscopic and microscopic tumor development compared with group fed with whey protein. The protocol applied to generate an appropriate model of colon cancer was successful. Whey protein hydrolyzate was found to be more effective in preventing colon tumor development compared with whey protein.
dc.identifier.doi10.1007/s12253-012-9509-9
dc.identifier.eissn1532-2807
dc.identifier.issn1219-4956
dc.identifier.pubmed22391964
dc.identifier.urihttps://hdl.handle.net/11424/230854
dc.identifier.wosWOS:000309104700009
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofPATHOLOGY & ONCOLOGY RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectColon cancer
dc.subjectAzoxymethane
dc.subjectDextran sodium sulfate
dc.subjectWhey protein
dc.subjectWhey protein hydrolyzate
dc.subjectPLASMA GLUTATHIONE LEVELS
dc.subjectANTIOXIDANT ACTIVITY
dc.subjectMICE
dc.subjectSUPPLEMENTATION
dc.subjectCARCINOGENESIS
dc.subjectEXPRESSION
dc.subjectCOLITIS
dc.subjectCANCER
dc.subjectSOY
dc.titleWhey Protein Versus Whey Protein Hydrolyzate for the Protection of Azoxymethane and Dextran Sodium Sulfate Induced Colonic Tumors in Rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id2bbd0841-c126-402d-b0c0-ee11cb1e0ce9
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage822
oaire.citation.issue4
oaire.citation.startPage817
oaire.citation.titlePATHOLOGY & ONCOLOGY RESEARCH
oaire.citation.volume18
relation.isAuthorOfPublication7a2bc583-aab6-43e7-9cc3-0d7a60773409
relation.isAuthorOfPublication.latestForDiscovery7a2bc583-aab6-43e7-9cc3-0d7a60773409

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