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The gingival crevicular fluid levels of growth factors in patients with amlodipine-induced gingival overgrowth: A pilot study

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dc.contributor.authorYILDIRIM, HATİCE SELİN
dc.contributor.authorsKose, K. N.; Yilmaz, S.; Noyan, U.; Kuru, B.; Yildirim, H. S.; Agrali, O. B.; Ozener, H. O.; Kuru, L.
dc.date.accessioned2022-03-12T22:42:44Z
dc.date.available2022-03-12T22:42:44Z
dc.date.issued2020
dc.description.abstractBackground: Amlodipine, calcium channel blocker (CCB), is used in the management of cardiovascular diseases which causes gingival overgrowth (GO). The growth factors may have a role in the pathogenesis of amlodipine-induced GO. Objectives: This pilot study aimed to investigate the growth factors including transforming growth factor-b1 (TGF-b1), platelet-derived growth factor-BB (PDGF-BB), and basic fibroblast growth factor (bFGF) in gingival crevicular fluid (GCF) of patients with amlodipine-induced GO and compare with of healthy subjects. Methods: GCF samples were collected from 56 sites presenting GO (GO + group) and from 38 sites not presenting GO (GO- group) of 5 patients using amlodipine for more than one year, and from 45 sites (control group) of 5 healthy subjects. The levels of TGF-b1, PDGF-BB, and bFGF were determined by using ELISA kits. Results: The mean concentration of TGF-b1 in GCF samples of GO + group (9.50 +/- 7.30 ng/ml) was higher than both GO- group (2.07 +/- 0.50 ng/ml) and control group (2.74 +/- 1.01 ng/ml) (P = 0.014). No significant difference was found among the groups in the GCF levels of PDGF-BB (P = 0.767). bFGF was detected in only 33% of the sites from patients. Conclusion: These preliminary results suggest that TGF-b1 may play a crucial role in the pathogenesis of amlodipine-induced GO.
dc.identifier.doi10.4103/njcp.njcp_532_19
dc.identifier.issn1119-3077
dc.identifier.pubmed32246666
dc.identifier.urihttps://hdl.handle.net/11424/236257
dc.identifier.wosWOS:000526948300018
dc.language.isoeng
dc.publisherWOLTERS KLUWER MEDKNOW PUBLICATIONS
dc.relation.ispartofNIGERIAN JOURNAL OF CLINICAL PRACTICE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAmlodipine
dc.subjectGingival overgrowth
dc.subjectgrowth factors
dc.subjectCALCIUM-CHANNEL BLOCKERS
dc.subjectFACTOR-BETA
dc.subjectCYCLOSPORINE-A
dc.subjectEXPRESSION
dc.subjectHYPERPLASIA
dc.subjectPREVALENCE
dc.subjectPHENYTOIN
dc.subjectPATHOGENESIS
dc.subjectNIFEDIPINE
dc.subjectTISSUES
dc.titleThe gingival crevicular fluid levels of growth factors in patients with amlodipine-induced gingival overgrowth: A pilot study
dc.typearticle
dspace.entity.typePublication
local.avesis.id367140d5-679d-4ddc-b007-3ef59c5d08c2
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
local.journal.quartileQ4
oaire.citation.endPage567
oaire.citation.issue4
oaire.citation.startPage561
oaire.citation.titleNIGERIAN JOURNAL OF CLINICAL PRACTICE
oaire.citation.volume23
relation.isAuthorOfPublication4024b22f-c25a-4b71-88ac-613d50ba3a90
relation.isAuthorOfPublication.latestForDiscovery4024b22f-c25a-4b71-88ac-613d50ba3a90

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