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Comparision of biocompatibility and cytotoxicity of two new root canal sealers

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dc.contributor.authorBECEREN, AYFER
dc.contributor.authorsGencoglu, Nimet; Sener, Goksel; Omurtag, Gulden Z.; Tozan, Ayfer; Uslu, Bahar; Arbak, Serap; Helvacioglu, Dilek
dc.date.accessioned2022-03-12T17:48:17Z
dc.date.available2022-03-12T17:48:17Z
dc.date.issued2010
dc.description.abstractThe aim of this study was to investigate the remote organ toxicity and connective tissue reaction of two new root canal sealers (GuttaFlowa(R) and EndoREZ(R)) and to compare them with zinc oxide eugenol sealer using biochemical and histopatho-logical parameters A total of 60 white albino Wistar rats were used in the study 0 1 ml of GuttaFlow(R), EndoREZ(R) or Kerr Pulp Canal Sealer(R) were administered subcutaneously into the mid dorsal thoracic region of rats (15 in each group) Control rats were given saline only Rats were decapitated after 24 h, on day 7 and on day 30 of the experiment and tissue samples from lung, liver, kidney and skin were removed for the determination of malondialdehyde (MDA) and glutathione (GSH) levels In parallel, tissues were also examined histologically Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels, and creatinine and blood urea nitrogen (BUN), concentrations (BUN) were measured to assess liver and kidney functions, respectively Tumor necrosis factor (TNF) and lactate dehydrogenase (LDH) were also assayed in serum samples No statistical differences were found among the control and EndoREZ(R), GuttaFlow(R) and Kerr Pulp Canal sealers regarding tissue MDA, GSH levels or serum parameters (p>0 05) at all time points examined Both of the new root canal sealers showed good compatibility and acceptable tissue toxicity (C) 2009 Elsevier GmbH All rights reserved
dc.identifier.doi10.1016/j.acthis.2009.06.005
dc.identifier.eissn1618-0372
dc.identifier.issn0065-1281
dc.identifier.pubmed19775730
dc.identifier.urihttps://hdl.handle.net/11424/229930
dc.identifier.wosWOS:000284865500006
dc.language.isoeng
dc.publisherELSEVIER GMBH
dc.relation.ispartofACTA HISTOCHEMICA
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiocompatibility
dc.subjectCytotoxicity
dc.subjectEndoREZ
dc.subjectGuttaFlow
dc.subjectKerr pulp canal sealer
dc.subjectRoot canal
dc.subjectRats
dc.subjectZINC-OXIDE
dc.subjectCOMPONENTS
dc.titleComparision of biocompatibility and cytotoxicity of two new root canal sealers
dc.typearticle
dspace.entity.typePublication
local.avesis.idafa64d58-b646-4a53-a524-be0479bcb8c0
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
oaire.citation.endPage575
oaire.citation.issue6
oaire.citation.startPage567
oaire.citation.titleACTA HISTOCHEMICA
oaire.citation.volume112
relation.isAuthorOfPublication759fae37-2af1-47e6-92f8-545c02df272b
relation.isAuthorOfPublication.latestForDiscovery759fae37-2af1-47e6-92f8-545c02df272b

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