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Production of 3D Printed Bi-Layer and Tri-Layer Sandwich Scaffolds with Polycaprolactone and Poly (vinyl alcohol)-Metformin towards Diabetic Wound Healing

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dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorsHarmanci S., Dutta A., Cesur S., Sahin A., Gunduz O., Kalaskar D. M., Ustundag C. B.
dc.date.accessioned2022-12-27T16:23:24Z
dc.date.available2022-12-27T16:23:24Z
dc.date.issued2022-12-01
dc.description.abstractType 2 diabetes mellitus (T2DM) is a chronic disease characterized by impaired insulin secretion, sensitivity, and hyperglycemia. Diabetic wounds are one of the significant complications of T2DM owing to its difficulty in normal healing, resulting in chronic wounds. In the present work, PCL/PVA, PCL/PVA/PCL, and metformin-loaded, PCL/PVA-Met and PCL/PVA-Met/PCL hybrid scaffolds with different designs were fabricated using 3D printing. The porosity and morphological analysis of 3D-printed scaffolds were performed using scanning electron microscopy (SEM). The scaffolds’ average pore sizes were between 63.6 ± 4.0 and 112.9 ± 3.0 µm. Molecular and chemical interactions between polymers and the drug were investigated with Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). Mechanical, thermal, and degradation analysis of the scaffolds were undertaken to investigate the physico-chemical characteristics of the scaffolds. Owing to the structure, PCL/PVA/PCL sandwich scaffolds had lower degradation rates than the bi-layer scaffolds. The drug release of the metformin-loaded scaffolds was evaluated with UV spectrometry, and the biocompatibility of the scaffolds on fibroblast cells was determined by cell culture analysis. The drug release in the PCL/PVA-Met scaffold was sustained till six days, whereas in the PCL/PVA-Met/PCL, it continued for 31 days. In the study of drug release kinetics, PCL/PVAMet and PCL/PVA-Met/PCL scaffolds showed the highest correlation coefficients (R2 ) values for the first-order release model at 0.8735 and 0.889, respectively. Since the layered structures in the literature are mainly obtained with the electrospun fiber structures, these biocompatible sandwich scaffolds, produced for the first time with 3D-printing technology, may offer an alternative to existing drug delivery systems and may be a promising candidate for enhancing diabetic wound healing.
dc.identifier.citationHarmanci S., Dutta A., Cesur S., Sahin A., Gunduz O., Kalaskar D. M., Ustundag C. B., "Production of 3D Printed Bi-Layer and Tri-Layer Sandwich Scaffolds with Polycaprolactone and Poly (vinyl alcohol)-Metformin towards Diabetic Wound Healing", POLYMERS, cilt.14, sa.23, 2022
dc.identifier.doi10.3390/polym14235306
dc.identifier.issn2073-4360
dc.identifier.issue23
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85143591588&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/284318
dc.identifier.volume14
dc.language.isoeng
dc.relation.ispartofPOLYMERS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKimya
dc.subjectFizikokimya
dc.subjectPolimer Karakterizasyonu
dc.subjectTemel Bilimler
dc.subjectChemistry
dc.subjectPhysical Chemistry
dc.subjectCharacterization of Polymers
dc.subjectNatural Sciences
dc.subjectPOLİMER BİLİMİ
dc.subjectTemel Bilimler (SCI)
dc.subjectPOLYMER SCIENCE
dc.subjectCHEMISTRY
dc.subjectNatural Sciences (SCI)
dc.subjectPolimerler ve Plastikler
dc.subjectKimya (çeşitli)
dc.subjectGenel Kimya
dc.subjectFizik Bilimleri
dc.subjectPolymers and Plastics
dc.subjectChemistry (miscellaneous)
dc.subjectGeneral Chemistry
dc.subjectPhysical Sciences
dc.subjectmetformin
dc.subjectdiabetic wound healing
dc.subjectdrug release
dc.subject3D-printed scaffold
dc.subjectsandwich scaffolds
dc.subjectMETFORMIN HYDROCHLORIDE
dc.subjectNANOFIBROUS SCAFFOLDS
dc.subjectCONTROLLED-RELEASE
dc.subjectTISSUE
dc.subjectFABRICATION
dc.subjectDRESSINGS
dc.subjectCOMPOSITES
dc.subjectCHITOSAN
dc.subjectGELATIN
dc.subjectmetformin
dc.subjectdiabetic wound healing
dc.subjectdrug release
dc.subject3D-printed scaffold
dc.subjectsandwich scaffolds
dc.titleProduction of 3D Printed Bi-Layer and Tri-Layer Sandwich Scaffolds with Polycaprolactone and Poly (vinyl alcohol)-Metformin towards Diabetic Wound Healing
dc.typearticle
dspace.entity.typePublication
local.avesis.idf3ddb06d-4a7a-4754-9a84-2d3afa289071
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublicationdda71138-8ce4-4265-89b2-73bc94786a4f
relation.isAuthorOfPublication.latestForDiscoverydda71138-8ce4-4265-89b2-73bc94786a4f

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