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Co-Culture of Keratinocyte-Staphylococcus aureus on Cu-Ag-Zn/CuO and Cu-Ag-W Nanoparticle Loaded Bacterial Cellulose:PMMA Bandages

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dc.contributor.authorYILMAZ, BETÜL
dc.contributor.authorsAltun, Esra; Aydogdu, Mehmet Onur; Crabbe-Mann, Maryam; Ahmed, Jubair; Brako, Francis; Karademir, Betul; Aksu, Burak; Sennaroglu, Muge; Eroglu, Mehmet S.; Ren, Guogang; Gunduz, Oguzhan; Edirisinghe, Mohan
dc.date.accessioned2022-03-14T09:17:54Z
dc.date.available2022-03-14T09:17:54Z
dc.date.issued2019-01
dc.description.abstractPressurized gyration and its sister processes are novel methods to produce polymeric fibers. Potential applications for such fibers include wound dressings, tissue engineering scaffolds, and filters. This study reports on a pressurized gyration technique that employs pressured N-2 gas to prepare biocompatible wound dressing bandages from bacterial cellulose and poly (methylmethacrylate) polymer blended with alloyed antimicrobial nanoparticles. Resulting bandages are manufactured with high product yield and characterized for their chemical, physical, and mechanical properties. Increased density in solutions with additional antimicrobial nanoparticles results in increased fiber diameters. Also, addition of antimicrobial nanoparticles enhances ultimate tensile strength and Young's modulus of the bandages. Typical molecular bonding in the bandages is confirmed by Fourier-transform infrared spectroscopy, with peaks that have higher intensity and narrowing points being caused by additional antimicrobial nanoparticles. More so, the cellular response to the bandages and the accompanying antimicrobial activity are studied in detail by in vitro co-culture of Staphylococcus aureus and keratinocytes. Antimicrobial nanoparticle-loaded bandage samples show increased cell viability and bacteria inhibition during co-culture and are found to have a promising future as epidermal wound dressing materials.
dc.identifier.doi10.1002/mame.201800537
dc.identifier.eissn1439-2054
dc.identifier.issn1438-7492
dc.identifier.urihttps://hdl.handle.net/11424/242930
dc.identifier.wosWOS:000458664400010
dc.language.isoeng
dc.publisherWILEY-V C H VERLAG GMBH
dc.relation.ispartofMACROMOLECULAR MATERIALS AND ENGINEERING
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectantimicrobial metallics
dc.subjectbacterial cellulose
dc.subjectbandage properties
dc.subjectcellular and bacteria co-cultures
dc.subjectpolymers
dc.subjectPOLYMER NANOFIBERS
dc.subjectFIBERS
dc.subjectSKIN
dc.subjectGYRATION
dc.subjectFIBROBLASTS
dc.subjectMEMBRANES
dc.subjectSTRENGTH
dc.subjectBEHAVIOR
dc.subjectPMMA
dc.titleCo-Culture of Keratinocyte-Staphylococcus aureus on Cu-Ag-Zn/CuO and Cu-Ag-W Nanoparticle Loaded Bacterial Cellulose:PMMA Bandages
dc.typearticle
dspace.entity.typePublication
local.avesis.id88c6ab48-7632-4fd5-b45e-85a71bbfd1c7
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.articlenumber1800537
local.journal.numberofpages14
local.journal.quartileQ1
oaire.citation.issue1
oaire.citation.titleMACROMOLECULAR MATERIALS AND ENGINEERING
oaire.citation.volume304
relation.isAuthorOfPublication81633a07-e5fb-4760-b3ef-bf0878d87827
relation.isAuthorOfPublication.latestForDiscovery81633a07-e5fb-4760-b3ef-bf0878d87827

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