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Increased Neutrophil/Lymphocyte Ratio in Patients with Depression is Correlated with the Severity of Depression and Cardiovascular Risk Factors

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dc.contributor.authorSARI, İBRAHİM
dc.contributor.authorsSunbul, Esra Aydin; Sunbul, Murat; Yanartas, Omer; Cengiz, Fatma; Bozbay, Mehmet; Sari, Ibrahim; Gulec, Huseyin
dc.date.accessioned2022-03-14T08:14:22Z
dc.date.available2022-03-14T08:14:22Z
dc.date.issued2016
dc.description.abstractObjective Chronic inflammation is associated with cardiovascular (CV) risk factors and psychiatric disorders. The neutrophil to lymphocyte ratio (NLR) has been investigated as a new biomarker for systemic inflammatory response. The aim of the study is to investigate the relation of NLR with severity of depression and CV risk factors. Methods The study population consisted of 256 patients with depressive disorder. Patients were evaluated with the Hamilton Rating Scale for Depression (HAM-D). Patients were classified into four groups according to their HAM-D score such as mild, moderate, severe, and very severe depression. Patients were also evaluated in terms of CV risk factors. Results Patients with higher HAM-D score had significantly higher NLR levels compared to patients with lower HAM-D score. Correlation analysis revealed that severity of depression was associated with NLR in depressive patients (r=0.333, p<0.001). Patients with one or more CV risk factors have significantly higher NLR levels. Correlation analysis revealed that CV risk factors were associated with NLR in depressive patients (r=0.132, p=0.034). In logistic regression analyses, NLR levels were an independent predictor of severe or very severe depression (odds ratio: 3.02, 95% confidence interval: 1.867-4.884, p<0.001). A NLR of 1.57 or higher predicted severe or very severe depression with a sensitivity of 61.4% and specificity of 61.2%. Conclusion Higher HAM-D scores are associated with higher NLR levels in depressive patients. NLR more than 1.57 was an independent predictor of severe or very severe depression. A simple, cheap white blood cell count may give an idea about the severity of depression.
dc.identifier.doi10.4306/pi.2016.13.1.121
dc.identifier.eissn1976-3026
dc.identifier.issn1738-3684
dc.identifier.pubmed26766954
dc.identifier.urihttps://hdl.handle.net/11424/241234
dc.identifier.wosWOS:000368650300014
dc.language.isoeng
dc.publisherKOREAN NEUROPSYCHIATRIC ASSOC
dc.relation.ispartofPSYCHIATRY INVESTIGATION
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDepression
dc.subjectLymphocyte
dc.subjectNeutrophil
dc.subjectInflammatory
dc.subjectCardiovascular risk
dc.subjectCORONARY-ARTERY-DISEASE
dc.subjectC-REACTIVE PROTEIN
dc.subjectLYMPHOCYTE RATIO
dc.subjectINFLAMMATORY MARKERS
dc.subjectNEUTROPHIL
dc.subjectASSOCIATION
dc.subjectMORTALITY
dc.subjectDISORDER
dc.subjectSCALE
dc.titleIncreased Neutrophil/Lymphocyte Ratio in Patients with Depression is Correlated with the Severity of Depression and Cardiovascular Risk Factors
dc.typearticle
dspace.entity.typePublication
local.avesis.id0f1f0d2e-e478-49e8-957b-fa70342046f5
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
local.journal.quartileQ3
oaire.citation.endPage126
oaire.citation.issue1
oaire.citation.startPage121
oaire.citation.titlePSYCHIATRY INVESTIGATION
oaire.citation.volume13
relation.isAuthorOfPublication26c97c3b-389c-4a43-9329-8693aa3c3333
relation.isAuthorOfPublication.latestForDiscovery26c97c3b-389c-4a43-9329-8693aa3c3333

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