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Poly(lactic acid) nanofibers containing phosphorylcholine grafts for transdermal drug delivery systems

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dc.contributor.authorOKTAY, BURCU
dc.contributor.authorDEMİR, SERAP
dc.contributor.authorKAYAMAN APOHAN, NİLHAN
dc.contributor.authorsOKTAY B., Eroglu G. O., DEMİR S., KURUCA D. S., KAYAMAN APOHAN N.
dc.date.accessioned2023-04-25T06:28:50Z
dc.date.available2023-04-25T06:28:50Z
dc.date.issued2022-06-01
dc.description.abstractThe continuous and prolonged releases of chemotherapeutic drugs are required for successful treatment in cancer treatment. The project focused on a new material design to meet this requirement. We developed a constant and sustained release system and investigated the release profiles of Paclitaxel (PTX). Polylactic acid (PLA) nanofiber surface was grafted with poly (methacryloyloxyethyl phosphorylcholine) (PMPC) by the UV-induced grafting method. The morphological structure of the PLA nanofibers did not change with an increase in the MPC content. PMPC blocks contribute to the solubility of PTX, which shows low resolution. When the amount of MPC is 5%, the PTX loading efficiency increased two times compared with PLA nanofiber. The nanofiber mats exhibited an initial fast release during the first 3 h. Endothelial cells were cultured on nanofiber mats to investigate whether this material was toxic or not. The mats showed good biocompatibility with HUVEC. Thus, it was confirmed that nanofiber mats would not be toxic when releasing drugs during in vivo use. We think that PMPC facilitates the pass of drugs through the lipid-rich biological membrane and so anticancer drugs can be delivered to direct tumor sites. (C) 2022 Elsevier Ltd. All rights reserved.
dc.identifier.citationOKTAY B., Eroglu G. O., DEMİR S., KURUCA D. S., KAYAMAN APOHAN N., "Poly(lactic acid) nanofibers containing phosphorylcholine grafts for transdermal drug delivery systems", MATERIALS TODAY SUSTAINABILITY, cilt.18, 2022
dc.identifier.doi10.1016/j.mtsust.2022.100132
dc.identifier.issn2589-2347
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S2589234722000240?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11424/288918
dc.identifier.volume18
dc.language.isoeng
dc.relation.ispartofMATERIALS TODAY SUSTAINABILITY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMühendislik ve Teknoloji
dc.subjectEngineering and Technology
dc.subjectMALZEME BİLİMİ, ÇOKDİSİPLİNLİ
dc.subjectMalzeme Bilimi
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectMATERIALS SCIENCE, MULTIDISCIPLINARY
dc.subjectMATERIALS SCIENCE
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectMetaller ve Alaşımlar
dc.subjectMalzeme Kimyası
dc.subjectGenel Malzeme Bilimi
dc.subjectFizik Bilimleri
dc.subjectMetals and Alloys
dc.subjectMaterials Chemistry
dc.subjectGeneral Materials Science
dc.subjectPhysical Sciences
dc.subjectDrug release
dc.subjectElectrospinning
dc.subjectPaclitaxel
dc.subjectUV-Grafting
dc.subjectCancer treatment
dc.subjectACCELERATED BLOOD CLEARANCE
dc.subjectPEGYLATED LIPOSOMES
dc.subjectCELL-ADHESION
dc.subjectPACLITAXEL
dc.subjectRELEASE
dc.subjectNANOPARTICLES
dc.subjectCOPOLYMER
dc.subjectPROLIFERATION
dc.subjectDOXORUBICIN
dc.titlePoly(lactic acid) nanofibers containing phosphorylcholine grafts for transdermal drug delivery systems
dc.typearticle
dspace.entity.typePublication
local.avesis.id47c9dd72-e84e-4f64-9ef9-8a304790bd10
local.indexed.atWOS
local.indexed.atSCOPUS
relation.isAuthorOfPublication73bf1f8b-c472-46a3-8ef3-f25a516fef62
relation.isAuthorOfPublication2790d85f-c14d-4e37-8567-e89f9e168058
relation.isAuthorOfPublication424650a0-1684-40b7-8868-3f624cef188e
relation.isAuthorOfPublication.latestForDiscovery73bf1f8b-c472-46a3-8ef3-f25a516fef62

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