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The Effects of Riluzole on Neurological, Brain Biochemical, and Histological Changes in Early and Late Term of Sepsis in Rats

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dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsToklu, Hale Z.; Uysal, Meral Keyer; Kabasakal, Levent; Sirvanci, Serap; Ercan, Feriha; Kaya, Mehmet
dc.date.accessioned2022-03-12T17:38:06Z
dc.date.available2022-03-12T17:38:06Z
dc.date.issued2009
dc.description.abstractObjective. One of the underlying mechanisms of sepsis is thought to be the oxidative damage due to the generation of free radicals. Glutamate, the major excitatory amino acid in the brain, is known to play an important role in blood brain barrier (BBB) permeability, brain edema, and oxidative damage in pathological conditions. Riluzole, a glutamate release inhibitor, has been shown to have neuroprotective effects in several animal models. The aim of our study was to investigate the putative protective effect of riluzole against sepsis-induced brain injury. Methods. Sepsis was induced by cecal ligation and puncture in Wistar albino rats. Sham operated (control) and sepsis groups received either saline or riluzole (6 mg/kg, s.c.) 30 min after the surgical procedure, and every 12 h as continuing treatment. The effect of riluzole on the survival rate, weight loss, fever, leukocyte count, brain edema, BBB permeability, oxidative damage, and histological observations were evaluated for early (6 h) and late (48 h) phase of sepsis. Results. Riluzole, when administered 6 mg/kg s.c., diminishes the sepsis-induced augmentation in weight loss, body temperature, brain edema, increase in BBB permeability, oxidative damage, and brain injury that is observed histologically. Besides increasing the survival rate in sepsis, it has also improved neurological examination scores and the prognosis of the disease. Conclusion. According to the results of this study, riluzole appears to have a protective effect for sepsis-induced encephalopathy. (C) 2009 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.jss.2008.03.013
dc.identifier.eissn1095-8673
dc.identifier.issn0022-4804
dc.identifier.pubmed18718604
dc.identifier.urihttps://hdl.handle.net/11424/229448
dc.identifier.wosWOS:000264501700009
dc.language.isoeng
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.relation.ispartofJOURNAL OF SURGICAL RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectriluzole
dc.subjectglutamate
dc.subjectsepsis
dc.subjectencephalopathy
dc.subjectblood brain barrier
dc.subjectantioxidant
dc.subjectneuroprotective
dc.subjectMDA
dc.subjectglutathione
dc.subjectCRITICAL ILLNESS POLYNEUROPATHY
dc.subjectOXIDATIVE STRESS
dc.subjectNEUROPROTECTIVE AGENT
dc.subjectATTENUATES EDEMA
dc.subjectTNF-ALPHA
dc.subjectGLUTAMATE
dc.subjectINJURY
dc.subjectDYSFUNCTION
dc.subjectMODEL
dc.subjectLIPOPOLYSACCHARIDE
dc.titleThe Effects of Riluzole on Neurological, Brain Biochemical, and Histological Changes in Early and Late Term of Sepsis in Rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id70b30ac2-ca69-4265-9b19-c8ec3a3480cd
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages11
oaire.citation.endPage248
oaire.citation.issue2
oaire.citation.startPage238
oaire.citation.titleJOURNAL OF SURGICAL RESEARCH
oaire.citation.volume152
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication.latestForDiscoveryadc800ed-105c-40c7-a572-6cf3f175be92

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