Publication:
Acute myeloid leukemia: New multiomics molecular signatures and implications for systems medicine diagnostics and therapeutics innovation

Simple item page
dc.contributor.authorARĞA, KAZIM YALÇIN
dc.contributor.authorTURANLI, BESTE
dc.contributor.authorYILMAZ, BETÜL
dc.contributor.authorsKelesoglu N., Kori M., TURANLI B., ARĞA K. Y., Yilmaz B., Duru O. A.
dc.date.accessioned2023-07-25T08:28:07Z
dc.date.available2023-07-25T08:28:07Z
dc.date.issued2022-07-01
dc.description.abstractAcute myeloid leukemia (AML) is a common, complex, and multifactorial malignancy of the hematopoietic system. AML diagnosis and treatment outcomes display marked heterogeneity and patient-to-patient variations. To date, AML-related biomarker discovery research has employed single omics inquiries. Multiomics analyses that reconcile and integrate the data streams from multiple levels of the cellular hierarchy, from genes to proteins to metabolites, offer much promise for innovation in AML diagnostics and therapeutics. We report, in this study, a systems medicine and multiomics approach to integrate the AML transcriptome data and reporter biomolecules at the RNA, protein, and metabolite levels using genome-scale biological networks. We utilized two independent transcriptome datasets (GSE5122, GSE8970) in the Gene Expression Omnibus database. We identified new multiomics molecular signatures of relevance to AML: miRNAs (e.g., mir-484 and miR-519d-3p), receptors (ACVR1 and PTPRG), transcription factors (PRDM14 and GATA3), and metabolites (in particular, amino acid derivatives). The differential expression profiles of all reporter biomolecules were crossvalidated in independent RNA-Seq and miRNA-Seq datasets. Notably, we found that PTPRG holds important prognostication potential as evaluated by Kaplan-Meier survival analyses. The multiomics relationships unraveled in this analysis point toward the genomic pathogenesis of AML. These multiomics molecular leads warrant further research and development as potential diagnostic and therapeutic targets.
dc.identifier.citationKelesoglu N., Kori M., TURANLI B., ARĞA K. Y., Yilmaz B., Duru O. A., "Acute Myeloid Leukemia: New Multiomics Molecular Signatures and Implications for Systems Medicine Diagnostics and Therapeutics Innovation", OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, cilt.26, sa.7, ss.392-403, 2022
dc.identifier.doi10.1089/omi.2022.0051
dc.identifier.endpage403
dc.identifier.issn1536-2310
dc.identifier.issue7
dc.identifier.startpage392
dc.identifier.urihttps://hdl.handle.net/11424/291538
dc.identifier.volume26
dc.language.isoeng
dc.relation.ispartofOMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Genetik
dc.subjectYaşam Bilimleri
dc.subjectBiyoteknoloji
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectMedical Genetics
dc.subjectLife Sciences
dc.subjectBiotechnology
dc.subjectMolecular Biology and Genetics
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectBİYOTEKNOLOJİ VE UYGULAMALI MİKROBİYOLOJİ
dc.subjectMikrobiyoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectGENETİK VE KALITIM
dc.subjectBIOTECHNOLOGY & APPLIED MICROBIOLOGY
dc.subjectMICROBIOLOGY
dc.subjectLife Sciences (LIFE)
dc.subjectGENETICS & HEREDITY
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectGenetik (klinik)
dc.subjectUygulamalı Mikrobiyoloji ve Biyoteknoloji
dc.subjectMoleküler Tıp
dc.subjectMoleküler Biyoloji
dc.subjectGenetik
dc.subjectGenetics (clinical)
dc.subjectApplied Microbiology and Biotechnology
dc.subjectMolecular Medicine
dc.subjectMolecular Biology
dc.subjectGenetics
dc.subjectacute myeloid leukemia
dc.subjectmultiomics
dc.subjectsystems medicine
dc.subjectbiomarkers
dc.subjectdrug targets
dc.subjectpersonalized medicine
dc.subjectGENOME-WIDE
dc.subjectREGULATORY NETWORK
dc.subjectEXPRESSION
dc.subjectCANCER
dc.subjectMETABOLISM
dc.subjectMICRORNAS
dc.subjectRECEPTOR
dc.subjectPTPRG
dc.subjectAML
dc.subjectIDENTIFICATION
dc.subjectAcute myeloid leukemia
dc.subjectBiomarkers
dc.subjectDrug targets
dc.subjectMultiomics
dc.subjectPersonalized medicine
dc.subjectSystems medicine
dc.titleAcute myeloid leukemia: New multiomics molecular signatures and implications for systems medicine diagnostics and therapeutics innovation
dc.typearticle
dspace.entity.typePublication
local.avesis.id04bd6705-0d74-49a4-aed5-dd807862c52c
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication3582c2d4-7fbb-4db7-8e90-75613782b894
relation.isAuthorOfPublication3e8c4f64-93ae-4b42-953c-35c8b07586b3
relation.isAuthorOfPublication81633a07-e5fb-4760-b3ef-bf0878d87827
relation.isAuthorOfPublication.latestForDiscovery3582c2d4-7fbb-4db7-8e90-75613782b894

Files

Collections

Research Outputs