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Estrogen receptor agonists alleviate cardiac and renal oxidative injury in rats with renovascular hypertension

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsKumral, Zarife Nigar Ozdemir; Kolgazi, Meltem; Ustunova, Savas; Cakir, Ozguer Kasimay; Cevik, Ozge Dagdeviren; Sener, Goksel; Yegen, Berrak C.
dc.date.accessioned2022-03-12T20:29:36Z
dc.date.available2022-03-12T20:29:36Z
dc.date.issued2016
dc.description.abstractAlthough endogenous estrogen is known to offer cardiac and vascular protection, the involvement of estrogen receptors in mediating the protective effect of estrogen on hypertension-induced cardiovascular and renal injury is not fully explained. We aimed to investigate the effects of estrogen receptor (ER) agonists on oxidative injury, cardiovascular and renal functions of rats with renovascular hypertension (RVH). Female Sprague-Dawley rats were randomly divided as control and RVH groups, and RVH groups had either ovariectomy (OVX) or sham-OVX. Sham-OVX-RVH and OVX-RVH groups received either ER agonist diarylpropiolnitrile (1 mg/kg/day) or ER agonist propyl pyrazole triol (1 mg/kg/day) for 6 weeks starting at the third week following the surgery. At the end of the 9(th) week, systolic blood pressures were recorded, cardiac functions were determined, and the contraction/relaxation responses of aortic rings were obtained. Serum creatinine levels, tissue malondialdehyde, glutathione, superoxide dismutase, catalase levels, and myeloperoxidase activity in heart and kidney samples were analyzed, and Na+, K+-ATPase activity was measured in kidney samples. In both sham-OVX and OVX rats, both agonists reduced blood pressure and reversed the impaired contractile performance of the heart, while ER agonist improved renal functions in both the OVX and non-OVX rats. Both agonists reduced neutrophil infiltration, lipid peroxidation, and elevated antioxidant levels in the heart, but a more ER-mediated protective effect was observed in the kidney. Our data suggest that activation of ER might play a role in preserving the function of the stenotic kidney and delaying the progression of renal injury, while both receptors mediate similar cardioprotective effects.
dc.identifier.doi10.3109/10641963.2015.1116550
dc.identifier.eissn1525-6006
dc.identifier.issn1064-1963
dc.identifier.pubmed27399230
dc.identifier.urihttps://hdl.handle.net/11424/234096
dc.identifier.wosWOS:000381406300002
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS INC
dc.relation.ispartofCLINICAL AND EXPERIMENTAL HYPERTENSION
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCardiac injury
dc.subjectestrogen receptor
dc.subjectmenopause
dc.subjectoxidative stress
dc.subjectrenal injury
dc.subjectrenovascular hypertension
dc.subjectCORONARY-HEART-DISEASE
dc.subjectORGAN DAMAGE
dc.subjectBLOOD-PRESSURE
dc.subjectALPHA
dc.subjectMECHANISMS
dc.subjectPROTECTS
dc.subjectSTRESS
dc.subjectACTIVATION
dc.subjectDEFICIENT
dc.subjectMENOPAUSE
dc.titleEstrogen receptor agonists alleviate cardiac and renal oxidative injury in rats with renovascular hypertension
dc.typearticle
dspace.entity.typePublication
local.avesis.id4b774d9c-f7b5-4e80-a7a4-bae26b6e06f5
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages10
local.journal.quartileQ4
oaire.citation.endPage509
oaire.citation.issue6
oaire.citation.startPage500
oaire.citation.titleCLINICAL AND EXPERIMENTAL HYPERTENSION
oaire.citation.volume38
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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