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The effects of inflammatory response associated with traumatic spinal cord injury in cutaneous wound healing and on expression of transforming growth factor-beta1 (TGF-beta(1)) and platelet-derived growth factor (PDGF)-A at the wound site in rats

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dc.contributor.authorAKAKIN, DİLEK
dc.contributor.authorsKonya, Deniz; Gercek, Arzu; Akakin, Akin; Akakin, Dilek; Tural, Selin; Cetinel, Sule; Ozgen, Serdar; Pamir, M. Necmettin
dc.date.accessioned2022-03-12T17:34:42Z
dc.date.available2022-03-12T17:34:42Z
dc.date.issued2008
dc.description.abstractAt the cellular level, spinal cord injury (SCI) provokes an inflammatory response that generates substantial secondary damage within the cord, but also may contribute to its repair. The aim of this study was to investigate the effects of inflammatory response associated with SCI in cutaneous wound healing and on expression of transforming growth factor-beta1 (TGF-beta(1)) and platelet-derived growth factor (PDGF)-A at the wound site in rats. At the 14th day analysis, the mean TGF-beta(1) score in trauma group (I) was significantly lower than that in control group (C) (2.60 +/- 0.90 vs. 3.64 +/- 0.37, respectively; p < 0.05). The mean score for PDGF-A expression in group I was similar to the corresponding value in group C (2.42 +/- 0.74 vs. 2.94 +/- 0.72, respectively). Compared to group C, group I had significantly lower mean scores for epidermal and dermal regeneration, but higher mean scores for granulation tissue thickness and similar scores for angiogenesis. The dermal layer contains diffuse deposition of collagen fibers that are not organised as in control rat skin, and intraepidermal and subepidermal vasocongestion is distinct. Based on the results on the parameters evaluated in the study, experimental SCI in rats results in delay in wound healing and low intensity of TGF-beta(1) in the dorsal wound-tissue specimens.
dc.identifier.doi10.1080/08977190802025339
dc.identifier.issn0897-7194
dc.identifier.pubmed18428026
dc.identifier.urihttps://hdl.handle.net/11424/229060
dc.identifier.wosWOS:000255221100002
dc.language.isoeng
dc.publisherINFORMA HEALTHCARE
dc.relation.ispartofGROWTH FACTORS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectplatelet derived growth factor
dc.subjectspinal cord injury
dc.subjecttransforming growth factor
dc.subjectwound healing
dc.subjectREPAIR
dc.subjectIMPACT
dc.titleThe effects of inflammatory response associated with traumatic spinal cord injury in cutaneous wound healing and on expression of transforming growth factor-beta1 (TGF-beta(1)) and platelet-derived growth factor (PDGF)-A at the wound site in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id06f979c7-9fe0-4bd8-9d46-20c843f77bb7
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage79
oaire.citation.issue2
oaire.citation.startPage74
oaire.citation.titleGROWTH FACTORS
oaire.citation.volume26
relation.isAuthorOfPublicationc97c0ebf-ffce-4b27-a933-941a53767b0d
relation.isAuthorOfPublication.latestForDiscoveryc97c0ebf-ffce-4b27-a933-941a53767b0d

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