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Morbid obesity leads to increased skin autofluorescence independent of metabolic syndrome components

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dc.contributor.authorAPAYDIN, TUĞÇE
dc.contributor.authorYAVUZ, DİLEK
dc.contributor.authorsAPAYDIN T., YAVUZ D.
dc.date.accessioned2022-12-02T12:59:52Z
dc.date.available2022-12-02T12:59:52Z
dc.date.issued2022-01-01
dc.description.abstractBackground/aim: Obesity, diabetes mellitus, and metabolic syndrome (MetS) are associated with increased accumulated skin advanced glycation end products. We aimed to evaluate the association of MetS components with skin autofluorescence (SAF) in patients with morbid obesity. Material and methods: Eight hundred and one patients with morbid obesity and 94 age-matched controls with normal body mass index (BMI) and normal glucose metabolism were included. Advanced glycation end products (AGEs) were measured using SAF in the forearm, with an AGE reader. Results: The prevalence of MetS in patients with morbid obesity was 65.5% (n = 525). Type 2 diabetes mellitus (type 2 DM) and hypertension were present in 40.9% (n = 328) and 43.7% (n = 357). Patients with morbid obesity and those with MetS had higher SAF measurements compared with the control group, 1.85 ± 0.44 arbitrary unit (AU) and 1.86 ± 0.43 AU vs. 1.72 ± 0.30 AU, respectively (p = 0.016). There was no difference in SAF levels between patients with and without MetS. SAF measurements of patients without MetS were not statistically different from the control group (p = 0.076). Patients with five MetS criteria had higher SAF measurements compared with patients with fewer MetS components (p = 0.019). There was no difference in SAF levels between patients with type 2 DM, impaired glucose metabolism, and patients with normal glucose metabolism (p = 0.513). Conclusion: Although MetS and type 2 DM are known as factors related to increased SAF levels, obesity can cause elevated SAF measurements in different ways independent of concomitant comorbid diseases. Larger studies with longer follow-ups are needed to enlighten the underlying mechanism.
dc.identifier.citationAPAYDIN T., YAVUZ D., "Morbid obesity leads to increased skin autofluorescence independent of metabolic syndrome components", TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.52, sa.4, ss.1085-1092, 2022
dc.identifier.doi10.55730/1300-0144.5411
dc.identifier.endpage1092
dc.identifier.issn1300-0144
dc.identifier.issue4
dc.identifier.startpage1085
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/9830bbdf-843c-4749-913e-249b0e1db24e/file
dc.identifier.urihttps://hdl.handle.net/11424/283512
dc.identifier.volume52
dc.language.isoeng
dc.relation.ispartofTURKISH JOURNAL OF MEDICAL SCIENCES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectMEDICINE, GENERAL & INTERNAL
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectGenel Sağlık Meslekleri
dc.subjectPatofizyoloji
dc.subjectTemel Bilgi ve Beceriler
dc.subjectDeğerlendirme ve Teşhis
dc.subjectDahiliye
dc.subjectAile Sağlığı
dc.subjectTıp (çeşitli)
dc.subjectGenel Tıp
dc.subjectGeneral Health Professions
dc.subjectPathophysiology
dc.subjectFundamentals and Skills
dc.subjectAssessment and Diagnosis
dc.subjectInternal Medicine
dc.subjectFamily Practice
dc.subjectMedicine (miscellaneous)
dc.subjectGeneral Medicine
dc.subjectAdvanced glycation end products
dc.subjectmetabolic syndrome
dc.subjectmorbid obesity
dc.subjectskin autofluorescence
dc.subjectGLYCATION END-PRODUCTS
dc.subjectBARIATRIC SURGERY
dc.subjectENDOTHELIAL DYSFUNCTION
dc.subjectNONINVASIVE MARKER
dc.subjectENDPRODUCTS
dc.subjectMORTALITY
dc.subjectRISK
dc.subjectAdvanced glycation end products
dc.subjectmetabolic syndrome
dc.subjectmorbid obesity
dc.subjectskin autofluorescence
dc.titleMorbid obesity leads to increased skin autofluorescence independent of metabolic syndrome components
dc.typearticle
dspace.entity.typePublication
local.avesis.id9830bbdf-843c-4749-913e-249b0e1db24e
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication26b8d3ef-e1b8-42bf-b031-ccc21ded403e
relation.isAuthorOfPublication26174ec5-7dca-4038-a7fe-9a43f236fd15
relation.isAuthorOfPublication.latestForDiscovery26b8d3ef-e1b8-42bf-b031-ccc21ded403e

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