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The synthesis of novel 4-(3,4-dimethoxyphenyl)chromenone-crown ethers and their cation binding, as determined using fluorescence spectra

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dc.contributor.authorSALAN, ÜMİT
dc.contributor.authorsGunduz, Cihan; Salan, Umit; Bulut, Mustafa
dc.date.accessioned2022-03-14T09:56:07Z
dc.date.available2022-03-14T09:56:07Z
dc.date.issued2009-12-01
dc.description.abstractThe complexation of naftifine (NF) and terbinafine (TB) with cyclodextrins (CDs) has been investigated by UV/visible and 1H NMR spectroscopy, ROESY techniques and also ESI-MS. Both drugs form 1:1 inclusion complexes with all the CDs tested except with -CD, as deduced from the Benesi-Hildebrand plots and confirmed by ESI-MS and NMR spectroscopy (Job plot method). The K11 values for NF decrease in the order -CDmethylated -CD2-hydroxypropyl--CD-CD. The determination of the enthalpy and entropy provides information about the main driving forces in the process. The stability constants of the complexes NF--CD, TB--CD and TB--CD determined by 1H NMR spectroscopy are in agreement with the values obtained by UV. For TB--CD, the value is higher, due to the fact that the length of the TB aliphatic chain allows a deeper inclusion of the naphthalene group inside the corresponding -CD molecule, according to the 2D ROESY experiments.
dc.identifier.doi10.1080/10610270902980606
dc.identifier.eissn1029-0478
dc.identifier.issn1061-0278
dc.identifier.urihttps://hdl.handle.net/11424/243703
dc.identifier.wosWOS:000274589100008
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofSUPRAMOLECULAR CHEMISTRY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectterbinafine
dc.subjectnaftifine
dc.subjectcyclodextrins
dc.subjectinclusion complex characterisation
dc.subjectCHROMENONE-CROWN-ETHERS
dc.subjectCOUMARIN DERIVATIVES
dc.subjectCOMPLEXATION
dc.subject4-PHENYLCOUMARINS
dc.subjectCONDUCTOMETRY
dc.subjectMACROCYCLES
dc.subjectMOLYBDENUM
dc.subjectELEMENTS
dc.subjectCESIUM
dc.subjectSERUM
dc.titleThe synthesis of novel 4-(3,4-dimethoxyphenyl)chromenone-crown ethers and their cation binding, as determined using fluorescence spectra
dc.typearticle
dspace.entity.typePublication
local.avesis.id10939348-5bb7-41f6-a8c3-14cec6d98f1f
local.import.packageSS16
local.indexed.atWOS
local.journal.articlenumberPII 914002358
local.journal.numberofpages8
oaire.citation.endPage731
oaire.citation.issue8
oaire.citation.startPage724
oaire.citation.titleSUPRAMOLECULAR CHEMISTRY
oaire.citation.volume21
relation.isAuthorOfPublication2ed24266-f5c6-4dda-acf9-8bb8372ca4ee
relation.isAuthorOfPublication.latestForDiscovery2ed24266-f5c6-4dda-acf9-8bb8372ca4ee

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