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A clinical scoring system to predict the development of intraventricular hemorrhage (IVH) in premature infants

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dc.contributor.authorsCoskun, Yesim; Isik, Semra; Bayram, Tevfik; Urgun, Kamran; Sakarya, Sibel; Akman, Ipek
dc.date.accessioned2022-03-12T22:26:17Z
dc.date.available2022-03-12T22:26:17Z
dc.date.issued2018
dc.description.abstractThe aim of this study is to develop a scoring system for the prediction of intraventricular hemorrhage (IVH) in preterm infants in the first 7 days of life. A prospective, clinical study was conducted in Bahcesehir University, Medical Park Goztepe Hospital Neonatal Intensive Care Unit, with the enrollment of 144 preterm infants with gestational age between 24 and 34 weeks. All preterms were followed up for IVH after birth until the 4th week of life. The demographic characteristics and clinical risk factors were noted. Risk factors were analyzed. The score was established after logistic regression analysis, considering the impact of each variable on the occurrence of IVH within the first 7 days of life. The IVH scores were further applied prospectively to 89 preterm infants as validation cohort. Low gestational age (GA), low Apgar score, and having bleeding diathesis were the most important risk factors for IVH. According to these risk factors, a scoring system was developed for IVH ranged from 0 to 5. According to the risk ratios (RR) obtained from the logistic regression model, low GA (ae 28 gestational week), presence of bleeding diathesis within 7 days, and low Apgar score increased the risk of IVH (RR = 3.32 for GA ae 28 gestational week, RR = 6.7 for presence of bleeding diathesis in 7th day, RR = 3 for having low Apgar score). The score was validated successfully in 89 infants. The area under ROC curve was 0.85 for derivation cohort and 0.807 for validation cohort. The predictive ability of the IVH score for derivation and validation cohort was calculated. The negative predictive values of a score less than 4 were 96.4 and 59.1%. Concerning IVH-related sequelae which continue to be a major public health problem, we have developed a feasible predictive model for evaluating the risk for developing IVH for preterm infants in the first 7 days of life.
dc.identifier.doi10.1007/s00381-017-3610-z
dc.identifier.eissn1433-0350
dc.identifier.issn0256-7040
dc.identifier.pubmed29026981
dc.identifier.urihttps://hdl.handle.net/11424/235042
dc.identifier.wosWOS:000419966300022
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofCHILDS NERVOUS SYSTEM
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIntraventricular hemorrhage
dc.subjectPreterm
dc.subjectPrediction
dc.subjectPRETERM INFANTS
dc.subjectRISK-FACTORS
dc.subjectPOSTHEMORRHAGIC HYDROCEPHALUS
dc.subjectPREVENTION
dc.subjectINFARCTION
dc.subjectINDOMETHACIN
dc.subjectMANAGEMENT
dc.subjectRESERVOIR
dc.subjectTHERAPY
dc.subjectMODEL
dc.titleA clinical scoring system to predict the development of intraventricular hemorrhage (IVH) in premature infants
dc.typearticle
dspace.entity.typePublication
local.avesis.id139d6bdc-d26f-41ab-9058-eb8805e7a8f4
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
local.journal.quartileQ3
oaire.citation.endPage136
oaire.citation.issue1
oaire.citation.startPage129
oaire.citation.titleCHILDS NERVOUS SYSTEM
oaire.citation.volume34

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