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Neurologic Adverse Events Associated with Voriconazole Therapy: Report of Two Pediatric Cases

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dc.contributor.authorERDEM ERALP, ELA
dc.contributor.authorsDemir, Sevliya Ocal; Atici, Serkan; Akkoc, Gulsen; Yakut, Nurhayat; Ikizoglu, Nilay Bas; Eralp, Ela Erdem; Soysal, Ahmet; Bakir, Mustafa
dc.date.accessioned2022-03-14T08:13:56Z
dc.date.available2022-03-14T08:13:56Z
dc.date.issued2016
dc.description.abstractAlthough voriconazole, a triazole antifungal, is a safe drug, treatment with this agent is associated with certain adverse events such as hepatic, neurologic, and visual disturbances. The current report presents two cases, one a 9-year-old boy and the other a 17-year-old girl, who experienced neurologic side effects associated with voriconazole therapy. Our aim is to remind readers of the side effects of voriconazole therapy in order to prevent unnecessary investigations especially for psychological and ophthalmologic problems. The first case was a 9-year-old boy with cystic fibrosis and invasive aspergillosis that developed photophobia, altered color sensation, and fearful visual hallucination. The second case was a 17-year-old girl with cystic fibrosis and allergic bronchopulmonary aspergillosis, and she experienced photophobia, fatigue, impaired concentration, and insomnia, when the dose of voriconazole therapy was increased from 12mg/kg/day to 16mg/kg/day. The complaints of the two patients disappeared after discontinuation of voriconazole therapy. Our experience in these patients reminded us of the importance of being aware of the neurologic adverse events associated with voriconazole therapy in establishing early diagnosis and initiating prompt treatment. In addition, although serum voriconazole concentration was not measured in the present cases, therapeutic drug monitoring for voriconazole seems to be critically important in preventing neurologic side effects in pediatric patients.
dc.identifier.doi10.1155/2016/3989070
dc.identifier.eissn2090-6633
dc.identifier.issn2090-6625
dc.identifier.pubmed27313918
dc.identifier.urihttps://hdl.handle.net/11424/241174
dc.identifier.wosWOS:000378117700001
dc.language.isoeng
dc.publisherHINDAWI LTD
dc.relation.ispartofCASE REPORTS IN INFECTIOUS DISEASES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAMPHOTERICIN-B
dc.subjectPHARMACOKINETICS
dc.subjectHALLUCINATIONS
dc.subjectFLUCONAZOLE
dc.subjectMULTICENTER
dc.titleNeurologic Adverse Events Associated with Voriconazole Therapy: Report of Two Pediatric Cases
dc.typearticle
dspace.entity.typePublication
local.avesis.id119c05ad-c8ac-40f4-8963-6f5bc943f492
local.import.packageSS16
local.indexed.atWOS
local.indexed.atPUBMED
local.journal.articlenumber3989070
local.journal.numberofpages3
oaire.citation.titleCASE REPORTS IN INFECTIOUS DISEASES
oaire.citation.volume2016
relation.isAuthorOfPublicationc12200d7-e88f-4fbb-ae60-0a5457f5462e
relation.isAuthorOfPublication.latestForDiscoveryc12200d7-e88f-4fbb-ae60-0a5457f5462e

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