Publication:
The role of circulating miRNAs in leptin resistance in obese children

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dc.contributor.authorHALİLOĞLU, BELMA
dc.contributor.authorsAltinkilic E. M., Bayrakdar S., Karabulut G. S., HALİLOĞLU B., Attar R.
dc.date.accessioned2023-05-02T09:51:48Z
dc.date.available2023-05-02T09:51:48Z
dc.date.issued2022-06-01
dc.description.abstractObjectives Leptin resistance is one of the important causes of obesity in children. Besides known causes of leptin resistance like mutations in leptin and leptin receptor genes, overexpression of SOCS3 in arcuate nucleus is a potential cause of leptin resistance. We aimed to determine the effects of circulating miRNAs on leptin resistance in obese children by targeting SOCS3 pathway. Methods miRNAs potentially targeting SOCS3 were determined by using online target prediction databases. Polymorphisms in miRNA target sequences were determined by using online genome browsers. miRNA expression levels of obese (n=35) and non-obese (n=30) children were determined by qPCR method, genotyping were performed by real-time PCR method and serum leptin, leptin receptor and SOCS3 levels were measured by ELISA method. Results miRNA profiling have shown that serum miR-218-5p levels are significantly (p<0.05) increased in accordance with serum leptin levels in obese children. Conclusions In this study we used target prediction methods for evaluating potential miRNAs which may involve in development of leptin resistance. We have shown that miR-218-5p might be taking part in leptin resistance in obese children.
dc.identifier.citationAltinkilic E. M., Bayrakdar S., Karabulut G. S., HALİLOĞLU B., Attar R., "The role of circulating miRNAs in leptin resistance in obese children", JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, cilt.35, ss.761-766, 2022
dc.identifier.doi10.1515/jpem-2022-0063
dc.identifier.endpage766
dc.identifier.issn0334-018X
dc.identifier.startpage761
dc.identifier.urihttps://hdl.handle.net/11424/289061
dc.identifier.volume35
dc.language.isoeng
dc.relation.ispartofJOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectÇocuk Sağlığı ve Hastalıkları
dc.subjectİç Hastalıkları
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectInternal Medicine Sciences
dc.subjectChild Health and Diseases
dc.subjectInternal Diseases
dc.subjectEndocrinology and Metabolic Diseases
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectPEDİATRİ
dc.subjectENDOCRINOLOGY & METABOLISM
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectPEDIATRICS
dc.subjectEndocrinology
dc.subjectEndocrine and Autonomic Systems
dc.subjectPediatrics
dc.subjectPediatrics, Perinatology and Child Health
dc.subjectEndocrinology, Diabetes and Metabolism
dc.subjectLife Sciences
dc.subjectchildhood obesity
dc.subjectcirculating miRNA
dc.subjectleptin resistance
dc.subjectSOCS3
dc.subjectMECHANISMS
dc.subjectMICRORNAS
dc.titleThe role of circulating miRNAs in leptin resistance in obese children
dc.typearticle
dspace.entity.typePublication
local.avesis.id956e8e1c-4037-432f-9da1-918d28194aa9
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication6987316d-bba9-4e45-a3de-1be3172f7827
relation.isAuthorOfPublication.latestForDiscovery6987316d-bba9-4e45-a3de-1be3172f7827

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