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Increased radiosensitivity and impaired DNA repair in patients with STAT3-LOF and ZNF341 deficiency, potentially contributing to malignant transformations

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dc.contributor.authorAYDINER, ELİF
dc.contributor.authorÖZEN, AHMET OĞUZHAN
dc.contributor.authorBARIŞ, SAFA
dc.contributor.authorsCekic S., Huriyet H., Hortoglu M., Kasap N., Ozen A. O., Karakoc-Aydiner E., Metin A., Ocakoglu G., Demiroz Abakay C., Temel S. G., et al.
dc.date.accessioned2023-05-08T08:06:41Z
dc.date.available2023-05-08T08:06:41Z
dc.date.issued2022-07-01
dc.description.abstractSTAT3 plays an important role in various complex and sometimes contradictory pathways such as proliferation, differentiation, migration, inflammation, and apoptosis. The transcriptional activity of the STAT3 gene is controlled by a transcription factor called ZNF341. There is insufficient data on radiation sensitivity and post-radiation DNA repair in STAT3- loss-of-function (LOF) patients. We aimed to investigate the radiosensitivity in patients with STAT3-LOF and ZNF341 deficiency. Twelve patients with STAT3-LOF and four ZNF341-deficiency patients were recruited from three clinical immunology centers in Turkey and evaluated for radiosensitivity by the Comet assay, comparing to 14 age- and sex-matched healthy controls. The tail length (TL) (mu m), percentage of DNA in the tail (TDNA%), and olive tail moment (OTM) (arbitrary units) were evaluated at the same time for baseline (spontaneous), initial (immediately after 2 Gy irradiation), and recovery (2 h after irradiation) periods by using a computerized image-analysis system, estimating DNA damage. Except for a patient with ZNF341 deficiency who developed nasal cell primitive neuroendocrine tumor and papillary thyroid cancer during the follow-up, there was no cancer in both groups. During the recovery period of irradiation, TL, TDNA%, and OTM values of healthy controls decreased rapidly toward the baseline, while these values of patients with STAT3-LOF and ZNF341 deficiency continued to increase, implying impaired DNA repair mechanisms. Increased radiosensitivity and impaired DNA repair were demonstrated in patients diagnosed with STAT3-LOF and ZNF341 deficiency, potentially explaining the susceptibility to malignant transformation.
dc.identifier.citationCekic S., Huriyet H., Hortoglu M., Kasap N., Ozen A. O., Karakoc-Aydiner E., Metin A., Ocakoglu G., Demiroz Abakay C., Temel S. G., et al., "Increased radiosensitivity and impaired DNA repair in patients with STAT3-LOF and ZNF341 deficiency, potentially contributing to malignant transformations", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, cilt.209, sa.1, ss.83-89, 2022
dc.identifier.doi10.1093/cei/uxac041
dc.identifier.endpage89
dc.identifier.issn0009-9104
dc.identifier.issue1
dc.identifier.startpage83
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/35511492/
dc.identifier.urihttps://hdl.handle.net/11424/289140
dc.identifier.volume209
dc.language.isoeng
dc.relation.ispartofCLINICAL AND EXPERIMENTAL IMMUNOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectLife Sciences
dc.subjectNatural Sciences
dc.subjectİmmünoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectIMMUNOLOGY
dc.subjectLife Sciences (LIFE)
dc.subjectGenel İmmünoloji ve Mikrobiyoloji
dc.subjectImmunology
dc.subjectGeneral Immunology and Microbiology
dc.subjectSTAT3-LOF
dc.subjectZNF-341 deficiency
dc.subjectradiosensitivity
dc.subjectDNA repair
dc.subjectComet assay
dc.subjectHYPER-IGE SYNDROME
dc.subjectENHANCES RADIOSENSITIVITY
dc.subjectCANCER-PATIENTS
dc.subjectIN-VITRO
dc.subjectMUTATIONS
dc.subjectDAMAGE
dc.subjectCELLS
dc.subjectSTAT3-LOF
dc.subjectZNF-341 deficiency
dc.subjectradiosensitivity
dc.subjectDNA repair
dc.subjectComet assay
dc.titleIncreased radiosensitivity and impaired DNA repair in patients with STAT3-LOF and ZNF341 deficiency, potentially contributing to malignant transformations
dc.typearticle
dspace.entity.typePublication
local.avesis.id8cb63832-c227-4f6c-a00a-4ed1ed2dec0d
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication787c2629-584b-4b3e-9850-bf85838f2973
relation.isAuthorOfPublication3e9c297b-e636-4836-8f61-dc9c8b7c29cf
relation.isAuthorOfPublication5b392475-f11d-44b3-b251-4fe8e6b7dbb9
relation.isAuthorOfPublication.latestForDiscovery787c2629-584b-4b3e-9850-bf85838f2973

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