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Significance of acanthosis nigricans in childhood obesity

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dc.contributor.authorBEREKET, ABDULLAH
dc.contributor.authorsGuran, Tulay; Turan, Serap; Akcay, Teoman; Bereket, Abdullah
dc.date.accessioned2022-03-12T17:33:26Z
dc.date.available2022-03-12T17:33:26Z
dc.date.issued2008
dc.description.abstractAim: Acanthosis nigricans (AN) is among the most common dermatologic manifestations of obesity and hyperinsulinism. In this study, we aimed to find the clinical and laboratory differences in obese children with AN and without AN (non-AN). Methods: In total, 160 obese children were included in the study. The duration of obesity, body mass index (BMI), BMI z-scores, birth weight, parental BMI, lipid profile, fasting and post-meal (PM) glucose and insulin levels were compared in 67 obese with AN and 93 obese without AN. Results: Age was similar in both groups. AN group had higher male to female ratio (42/25 in AN, 43/50 in non-AN; P = 0.03), higher BMI (30.3 +/- 6.1 in AN, 26.4 +/- 3.6 in non-AN; P < 0.001) and weight for height (162.6 +/- 28.8 in AN, 144.6 +/- 15.8 in non-AN; P < 0.001) than non-AN group. There were no significant differences between the groups in birth weight, parental BMI and blood pressure. AN group had higher fasting (19.9 +/- 16.2 mU/L in AN, 10.4 +/- 7.6 mU/L in non-AN; P < 0.001) and PM insulin (88.6 +/- 87.3 mU/L in AN, 51.1 +/- 42.0 mU/L in non-AN; P = 0.01) and homeostasis model assessment for insulin resistance (HOMA-IR) (4.0 +/- 2.5 in AN, 2.2 +/- 1.8 in non-AN; P < 0.001) than non-AN group. However, fasting and PM glucose, triglyceride, low-density lipoprotein-, high-density lipoprotein- and total cholesterol levels were similar in both groups. BMI was correlated with HOMA-IR in both groups (r = 0.40 for AN, r = 0.28 for non-AN). PM glucose and PM insulin were correlated in both groups (r = 0.56 for AN, r = 0.39 for non-AN). However, fasting glucose and fasting insulin were correlated in only non-AN (r = 0.25), but not in AN group. Conclusions: Obese children with AN show higher insulin levels and HOMA-IR. AN is an important predictor of the insulin resistance in childhood obesity. Insulin secretory dynamics seem to be disrupted in fasting state initially, which is reflected as the loss of fasting insulin-glucose correlation in AN group.
dc.identifier.doi10.1111/j.1440-1754.2007.01272.x
dc.identifier.issn1034-4810
dc.identifier.pubmed18476925
dc.identifier.urihttps://hdl.handle.net/11424/228844
dc.identifier.wosWOS:000255716000006
dc.language.isoeng
dc.publisherWILEY-BLACKWELL
dc.relation.ispartofJOURNAL OF PAEDIATRICS AND CHILD HEALTH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectacanthosis nigricans
dc.subjectchildhood
dc.subjectinsulin resistance
dc.subjectobesity
dc.subjectINSULIN-RESISTANCE
dc.subjectDIABETES RISK
dc.subjectCHILDREN
dc.subjectADOLESCENTS
dc.subjectPREVALENCE
dc.subjectAMERICAN
dc.subjectMARKER
dc.titleSignificance of acanthosis nigricans in childhood obesity
dc.typearticle
dspace.entity.typePublication
local.avesis.idd785bcd3-1332-4f60-825a-a41944fafe28
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages4
oaire.citation.endPage341
oaire.citation.issue6
oaire.citation.startPage338
oaire.citation.titleJOURNAL OF PAEDIATRICS AND CHILD HEALTH
oaire.citation.volume44
relation.isAuthorOfPublication669e9474-4e39-453f-a4bc-4ede9cb5abac
relation.isAuthorOfPublication.latestForDiscovery669e9474-4e39-453f-a4bc-4ede9cb5abac

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