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Protective effect of resveratrol against naphthalene-induced oxidative stress in mice

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dc.contributor.authorBECEREN, AYFER
dc.contributor.authorsSehirli, Oezer; Tozan, Ayfer; Omurtag, Guelden Z.; Cetinel, Sule; Contuk, Gazi; Gedlk, Nursal; Sener, Goeksel
dc.date.accessioned2022-03-12T17:34:22Z
dc.date.available2022-03-12T17:34:22Z
dc.date.issued2008
dc.description.abstractObjective: This investigation confirms the role of free radicals in naphthalene-induced toxicity and elucidates the mechanism of resveratrol (RVT). Methods: Both male and female BALB-c mice were administered with naphthalene (100mg/kg, i.p.) for 30 days, either along with saline or along with RVT (10 mg/kg, orally). At the end of the experiment, following treatment and sacrifice of animals by decapitation, lung, liver and kidney tissue samples were taken for histological examination or determination of malondialdehyde (MDA), glutathione (GSH), myeloperoxidase (MPO) activity and collagen contents. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN) and creatinine levels and lactate dehydrogenase (LDH) activity were measured in the serum samples, while TNF-alpha, IL-beta, IL-6 and total antioxidant capacity (AOC) were assayed in plasma samples. Results: Naphthalene administration caused a significant decrease in tissue GSH and plasma AOC, which was accompanied with significant increases in tissue MDA and collagen levels and MPO activity. Moreover, the pro-inflammatory mediators (TNF-alpha, IL-beta, IL-6), LDH activity, AST, ALT, creatinine and BUN levels were significantly increased in the naphthalene group. On the other hand, RVT treatment reversed all these biochemical indices as well as histopathological alterations induced by naphthalene. Conclusions: Oxidative mechanisms play an important role in naphthalene-induced tissue damage, and RVT, by inhibiting neutrophil infiltration, balancing oxidant-antioxidant status, and regulating the generation of inflammatory mediators, ameliorates oxidative organ injury due to naphthalene toxicity. (C) 2007 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.ecoenv.2007.08.023
dc.identifier.issn0147-6513
dc.identifier.pubmed18261796
dc.identifier.urihttps://hdl.handle.net/11424/229010
dc.identifier.wosWOS:000258550400034
dc.language.isoeng
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.relation.ispartofECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectnaphthalene
dc.subjectresveratrol
dc.subjectlipid peroxidation
dc.subjectglutathione
dc.subjectmyeloperoxidase
dc.subjectWINE CONSTITUENT POLYPHENOL
dc.subjectAQUEOUS GARLIC EXTRACT
dc.subjectRED WINE
dc.subjectINDUCED TOXICITY
dc.subjectTISSUE-DAMAGE
dc.subjectVITAMIN-E
dc.subjectRATS
dc.subjectGLUTATHIONE
dc.subjectMECHANISM
dc.subjectMELATONIN
dc.titleProtective effect of resveratrol against naphthalene-induced oxidative stress in mice
dc.typearticle
dspace.entity.typePublication
local.avesis.iddacd78cd-708d-42e2-8d6b-1742f7a3f6c5
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage308
oaire.citation.issue1
oaire.citation.startPage301
oaire.citation.titleECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
oaire.citation.volume71
relation.isAuthorOfPublication759fae37-2af1-47e6-92f8-545c02df272b
relation.isAuthorOfPublication.latestForDiscovery759fae37-2af1-47e6-92f8-545c02df272b

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