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Development and Evaluation of Combined Effect Buccal Films for Treatment of Oral Candidiasis

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dc.contributor.authorDURMUŞOĞLU, LÜTFİYE
dc.contributor.authorsArslan D., AKBAL DAĞISTAN Ö., SAĞIRLI A. O., DURMUŞOĞLU L., CEVHER E., Yildiz-Pekoz A.
dc.date.accessioned2023-01-02T11:16:40Z
dc.date.available2023-01-02T11:16:40Z
dc.date.issued2023-01-01
dc.description.abstract© 2022, The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.Buccal film formulations, including antifungal nystatin, anti-inflammatory agent hydrocortisone acetate, and local anesthetic lidocaine hydrochloride for pain relief, were developed. Bioadhesive films were fabricated with hydrophilic polymers, hydroxyethyl cellulose (HEC), and xanthan gum (XG) and dried in the incubator. Textural, swelling, and bioadhesive properties, physicochemical and in vitro release characteristics, and antifungal activities of bioadhesive films were evaluated. Bioadhesive films significantly extended nystatin release by prolonging retention time of the target area formulation while rapidly releasing hydrocortisone acetate and lidocaine HCl, reducing drug administration. The polymer type affected bioadhesion strength and erosion ratio, and XG formulations had more polymer suitability. Consequently, XT-O2 formulation that was prepared with xanthan gum and tween 80, was best for its highest antifungal film activity (20.00 ± 0.07 mm), released nystatin (44.296% ± 1.695), and lowest erosion matrix (36.719% ± 0.249). The selected formulation can be used for compatibility, stability and in vivo studies targeted oral candidiasis infections. Graphical Abstract: [Figure not available: see fulltext.]
dc.identifier.citationArslan D., AKBAL DAĞISTAN Ö., SAĞIRLI A. O., DURMUŞOĞLU L., CEVHER E., Yildiz-Pekoz A., "Development and Evaluation of Combined Effect Buccal Films for Treatment of Oral Candidiasis", AAPS PharmSciTech, cilt.24, sa.1, 2023
dc.identifier.doi10.1208/s12249-022-02477-5
dc.identifier.issn1530-9932
dc.identifier.issue1
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85144284150&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/284670
dc.identifier.volume24
dc.language.isoeng
dc.relation.ispartofAAPS PharmSciTech
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTROPİKAL TIP
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectTROPICAL MEDICINE
dc.subjectFarmasötik bilim
dc.subjectYaşam Bilimleri
dc.subjectPharmaceutical Science
dc.subjectLife Sciences
dc.subjectbuccal drug delivery
dc.subjecthydrocortisone acetate
dc.subjectlidocaine hydrochloride
dc.subjectmucoadhesive film
dc.subjectnystatin
dc.subjectoral candidiasis
dc.subjectxanthan gum
dc.titleDevelopment and Evaluation of Combined Effect Buccal Films for Treatment of Oral Candidiasis
dc.typearticle
dspace.entity.typePublication
local.avesis.ida73be89b-90f7-4aa7-b32f-dc08c6580eff
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication05614eca-392c-4f70-a728-f6fec5586b16
relation.isAuthorOfPublication.latestForDiscovery05614eca-392c-4f70-a728-f6fec5586b16

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