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Cumene hydroperoxide-induced chemiluminescence in human erythrocytes: effect of antioxidants and sulfhydryl compounds

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dc.contributor.authorYALÇIN, AHMET SUHA
dc.contributor.authorsYalçin, A. S.; Sabuncu, N.; Emerk, K.
dc.date.accessioned2022-03-15T11:11:06Z
dc.date.available2022-03-15T11:11:06Z
dc.date.issued1992
dc.description.abstract1. The time-course of cumene hydroperoxide-induced changes in lipid peroxidation, protein sulfhydryl groups and chemiluminescence intensity was determined in human erythrocytes. 2. Increase in lipid peroxidation was maximal within 60 min of incubation and was paralleled by a decrease in protein sulfhydryl groups and an increase in chemiluminescence formation. 3. A standard assay system was established to investigate the protective effects of antioxidants and scavenger compounds on cumene hydroperoxide-induced chemiluminescence formation. 4. Chain-breaking antioxidants (i.e. butylated hydroxytoluene) and sulfhydryl compounds (i.e. dithiothreitol) were able to suppress chemiluminescence formation. 5. Our results suggested that secondary free radicals, as well as sulfhydryl groups of proteins are involved in cumene hydroperoxide-induced chemiluminescence formation.
dc.identifier.doi10.1016/0020-711x(92)90045-3
dc.identifier.issn0020-711X
dc.identifier.pubmedPMID: 1551463
dc.identifier.urihttps://hdl.handle.net/11424/248849
dc.language.isoeng
dc.relation.ispartofThe International Journal of Biochemistry
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHumans
dc.subjectAntioxidants
dc.subjectSulfhydryl Compounds
dc.subjectLipid Peroxidation
dc.subjectKinetics
dc.subjectLuminescent Measurements
dc.subjectFree Radical Scavengers
dc.subjectErythrocytes
dc.subjectBenzene Derivatives
dc.subjectButylated Hydroxytoluene
dc.subjectDithiothreitol
dc.titleCumene hydroperoxide-induced chemiluminescence in human erythrocytes: effect of antioxidants and sulfhydryl compounds
dc.typearticle
dspace.entity.typePublication
local.avesis.id92cc421c-9f22-4e42-97d5-51eb04501800
local.import.packageSS23
local.import.sourcePubMed
local.indexed.atPUBMED
oaire.citation.endPage502
oaire.citation.startPage499
oaire.citation.titleThe International Journal of Biochemistry
oaire.citation.volume3
relation.isAuthorOfPublication7a2bc583-aab6-43e7-9cc3-0d7a60773409
relation.isAuthorOfPublication.latestForDiscovery7a2bc583-aab6-43e7-9cc3-0d7a60773409

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