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Grape seed extract treatment reduces hepatic ischemia-reperfusion injury in rats

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dc.contributor.authorDULUNDU, ENDER
dc.contributor.authorsSehirli, Ozer; Ozel, Yahya; Dulundu, Ender; Topaloglu, Umit; Ercan, Feriha; Sener, Goksel
dc.date.accessioned2022-03-14T08:29:23Z
dc.date.available2022-03-14T08:29:23Z
dc.date.issued2008-01
dc.description.abstractThis study was designed to determine the possible protective effect of grape seed extract (GSE), a widely used antioxidant dietary supplement, on hepatic ischemia/reperfusion (I/R) injury. Wistar albino rats were subjected to 45 min of hepatic ischemia, followed by a 60 min reperfusion period. GSE was administered in a dose of 50 mg/kg/day orally for 15 days before (I/R) injury and repeated before the reperfusion period. Liver samples were taken for histological examination or determination of hepatic malondialdehyde (MDA), glutathione (GSH) and myeloperoxidase (MPO) activity. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were determined to assess liver functions. Lactate dehydrogenase (LDH) and cytokines (TNF-alpha and IL-1 beta) were also assayed in serum samples for the evaluation of generalized tissue damage. Ischemia/reperfusion caused a significant decrease in hepatic GSH, and significant increases in MDA level, and MPO activity. Serum AST and ALT levels, as well as LDH activity and plasma TNF-alpha and IL-1 beta levels were also elevated in the I/R group. Treatment with GSE reversed all these biochemical parameters as well as histological alterations induced by I/R. In conclusion, GSE reduced I/R-induced organ injury through its ability to balance the oxidant-antioxidant status, to inhibit neutrophil infiltration and to regulate the release of inflammatory mediators. Copyright (c) 2007 John Wiley & Sons, Ltd.
dc.identifier.doi10.1002/ptr.2256
dc.identifier.issn0951-418X
dc.identifier.pubmed18165941
dc.identifier.urihttps://hdl.handle.net/11424/241869
dc.identifier.wosWOS:000252713900008
dc.language.isoeng
dc.publisherJOHN WILEY & SONS LTD
dc.relation.ispartofPHYTOTHERAPY RESEARCH
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectischemia/reperfusion
dc.subjectgrape seed extract
dc.subjectlipid peroxidation
dc.subjectglutathione
dc.subjectmyeloperoxidase
dc.subjectPROANTHOCYANIDIN EXTRACT
dc.subjectFREE-RADICALS
dc.subjectANTIOXIDANT ACTIVITY
dc.subjectTISSUE-INJURY
dc.subjectLIVER
dc.subjectISCHEMIA/REPERFUSION
dc.subjectTRANSPLANTATION
dc.subjectMECHANISMS
dc.subjectFLAVONOIDS
dc.subjectPROTECTION
dc.titleGrape seed extract treatment reduces hepatic ischemia-reperfusion injury in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.idf2776456-a5ec-4095-aaec-68d32939ab6d
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage48
oaire.citation.issue1
oaire.citation.startPage43
oaire.citation.titlePHYTOTHERAPY RESEARCH
oaire.citation.volume22
relation.isAuthorOfPublicationedcd2255-94d5-4f56-b0c8-1385c55279b0
relation.isAuthorOfPublication.latestForDiscoveryedcd2255-94d5-4f56-b0c8-1385c55279b0

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