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Effects of hyperbaric oxygen therapy on caustic esophageal injury in rats

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dc.contributor.authorKIYAN, GÜRSU
dc.contributor.authorsKiyan, G; Aktas, S; Ozel, K; Isbilen, E; Kotiloglu, E; Dagli, TE
dc.date.accessioned2022-03-12T17:17:14Z
dc.date.available2022-03-12T17:17:14Z
dc.date.issued2004
dc.description.abstractBackground/Purpose: Caustic esophageal burn is a serious problem in pediatric surgery. Even though many clinical and experimental studies had been performed, the complication rate could not be reduced to a satisfying level. In this study, the authors evaluated the effects of hyperbaric oxygen (HBO) therapy in caustic esophageal burn in-rats. Methods: Rats were divided into 4 groups, and caustic burn at the distal esophagus was created by applying 50% NaOH for 3 minutes in all groups. The first and third groups did not receive HBO therapy. HBO therapy was applied to the second group for 2 days and to the fourth group for 28 days. To evaluate the effects of short-term HBO therapy, the first 2 groups were compared for ulceration, inflammation, and submucosal vascular thrombosis after 2 days. The third and fourth groups were compared for the long-term effects of HBO therapy. Rats in these groups were killed after 28 days and compared for the collagen content, weight, and mortality rate. Results: In the second group, which received 2 days of HBO therapy, ulcer depth and vascular thrombosis were significantly lower than these in the first group (P = .022 and P = .020, respectively). The fourth group, which received 4 weeks of HBO therapy, had a significantly reduced mortality rate, weight loss, and collagen score and hydroxyproline level if compared with the third group (P = .035; P = .016; P = .028; and P = .033, respectively). Conclusions: These results indicate that HBO therapy is useful in caustic esophageal burn both in short-term and longterm use. (C) 2004 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.jpedsurg.2004.04.012
dc.identifier.eissn1531-5037
dc.identifier.issn0022-3468
dc.identifier.pubmed15300524
dc.identifier.urihttps://hdl.handle.net/11424/227798
dc.identifier.wosWOS:000223768400005
dc.language.isoeng
dc.publisherW B SAUNDERS CO-ELSEVIER INC
dc.relation.ispartofJOURNAL OF PEDIATRIC SURGERY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjecthyperbaric oxygen
dc.subjectcaustic burn
dc.subjectEPIDERMAL GROWTH-FACTOR
dc.subjectCONSERVATIVE TREATMENT
dc.subjectCORROSIVE STRICTURES
dc.subjectBURNS
dc.subjectCHILDREN
dc.subjectMANAGEMENT
dc.subjectCHILDHOOD
dc.titleEffects of hyperbaric oxygen therapy on caustic esophageal injury in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.idf6defd85-8779-4cd8-a7a3-8a988f28196a
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage1193
oaire.citation.issue8
oaire.citation.startPage1188
oaire.citation.titleJOURNAL OF PEDIATRIC SURGERY
oaire.citation.volume39
relation.isAuthorOfPublicationbd406bf9-3ea7-49aa-b786-64b01b185e1e
relation.isAuthorOfPublication.latestForDiscoverybd406bf9-3ea7-49aa-b786-64b01b185e1e

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