Publication:
The gastroprotective effect of obestatin on indomethacin-induced acute ulcer is mediated by a vagovagal mechanism

Simple item page
dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsSen, Leyla Semiha; Kumral, Zarife Nigar Ozdemir; Memi, Gulsun; Ercan, Feriha; Yegen, Berrak C.; Yegen, Cumhur
dc.date.accessioned2022-03-14T10:15:10Z
dc.date.available2022-03-14T10:15:10Z
dc.date.issued2020-06
dc.description.abstractIn order to investigate the role of the vagus nerve in the possible gastroprotective effect of obestatin on the indomethacin-induced acute oxidative gastric injury, Sprague-Dawley rats of both sexes were injected subcutaneously with indomethacin (25 mg/kg, 5% NaHCO3) followed by obestatin (10, 30 or 100 mu g/kg). In other sets of rats, surgical vagotomy (Vx) or selective degeneration of vagal afferent fibers by perivagal capsaicin was performed before the injections of indomethacin or indomethacin + obestatin (30 mu g/kg). Gastric serosal blood flow was measured, and 4 h after ulcer induction gastric tissue samples were taken for histological and biochemical assays. Obestatin reduced the severity of indomethacin-induced acute ulcer via the reversal of reactive hyperemia, by inhibiting ulcer-induced neutrophil infiltration and lipid peroxidation along with the replenishment of glutathione (GSH) stores, whereas Vx abolished the inhibitory effect of obestatin on blood flow and lipid peroxidation, and worsened the severity of ulcer. On the other hand, serosal blood flow was even amplified by the selective denervation of the capsaicin-sensitive vagal afferent fibers, but obestatin-induced reduction in ulcer severity was not altered. In conclusion, the gastroprotective effect of obestatin on indomethacin-induced ulcer appears to involve the activation of the vagovagal pathway.
dc.identifier.doi10.1556/2060.2020.00025
dc.identifier.issn2498-602X
dc.identifier.pubmed32692714
dc.identifier.urihttps://hdl.handle.net/11424/244263
dc.identifier.wosWOS:000579856600006
dc.language.isoeng
dc.publisherAKADEMIAI KIADO ZRT
dc.relation.ispartofPHYSIOLOGY INTERNATIONAL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNSAID
dc.subjectobestatin
dc.subjectvagus
dc.subjectneutrophil
dc.subjectcapsaicin
dc.subjecthyperemia
dc.subjectindomethacin
dc.subjectGASTRIC-MUCOSAL INJURY
dc.subjectBLOOD-FLOW
dc.subjectVAGUS NERVE
dc.subjectGHRELIN
dc.subjectDAMAGE
dc.subjectRATS
dc.subjectACTIVATION
dc.subjectPATHOGENESIS
dc.subjectINFLAMMATION
dc.subjectPROTECTS
dc.titleThe gastroprotective effect of obestatin on indomethacin-induced acute ulcer is mediated by a vagovagal mechanism
dc.typearticle
dspace.entity.typePublication
local.avesis.id950a163c-7eef-4e4a-b195-02ec8a26f8e9
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages13
local.journal.quartileQ4
oaire.citation.endPage255
oaire.citation.issue2
oaire.citation.startPage243
oaire.citation.titlePHYSIOLOGY INTERNATIONAL
oaire.citation.volume107
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
article-p243.pdf
Size:
1.88 MB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs