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Comprehensive Chemical Profiling and Multidirectional Biological Investigation of Two Wild Anthemis Species (Anthemis tinctoria var. Pallida and A. cretica subsp. tenuiloba): Focus on Neuroprotective Effects

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dc.contributor.authorŞENKARDEŞ, İSMAİL
dc.contributor.authorsOrlando, Giustino; Zengin, Gokhan; Ferrante, Claudio; Ronci, Maurizio; Recinella, Lucia; Senkardes, Ismail; Gevrenova, Reneta; Zheleva-Dimitrova, Dimitrina; Chiavaroli, Annalisa; Leone, Sheila; Di Simone, Simonetta; Brunetti, Luigi; Picot-Allain, Carene Marie Nancy; Mahomoodally, Mohamad Fawzi; Sinan, Kouadio Ibrahime; Menghini, Luigi
dc.date.accessioned2022-03-14T09:06:33Z
dc.date.available2022-03-14T09:06:33Z
dc.date.issued2019-07-16
dc.description.abstractEthyl acetate (EA), methanol (MeOH), and aqueous extracts of aerial parts of Anthemis tinctoria var. pallida (ATP) and A. cretica subsp. tenuiloba (ACT) were investigated for their phenol and flavonoid content, antioxidant, and key enzyme inhibitory potentials. All extracts displayed antiradical effects, with MeOH and aqueous extracts being a superior source of antioxidants. On the other hand, EA and MeOH extracts were potent against AChE and BChE. Enzyme inhibitory effects against tyrosinase and alpha-glucosidase were observed, as well. We also studied Anthemis extracts in an ex vivo experimental neurotoxicity paradigm. We assayed extract influence on oxidative stress and neurotransmission biomarkers, including lactate dehydrogenase (LDH) and serotonin (5-HT), in isolated rat cortex challenged with K+ 60 mM Krebs-Ringer buffer (excitotoxicity stimulus). An untargeted proteomic analysis was finally performed in order to explore the putative mechanism in the brain. The pharmacological study highlighted the capability of ACT water extract to blunt K+ 60 mM increase in LDH level and 5-HT turnover, and restore physiological activity of specific proteins involved in neuron morphology and neurotransmission, including NEFMs, VAMP-2, and PKC gamma, thus further supporting the neuroprotective role of ACT water extract.
dc.identifier.doi10.3390/molecules24142582
dc.identifier.eissn1420-3049
dc.identifier.pubmed31315236
dc.identifier.urihttps://hdl.handle.net/11424/242526
dc.identifier.wosWOS:000482303000065
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofMOLECULES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnthemis
dc.subjectoxidative stress
dc.subjectneurotransmission
dc.subjectproteomic
dc.subjectphytomedicine
dc.subjectESSENTIAL OIL
dc.subjectANTIMICROBIAL ACTIVITY
dc.subjectTRANSIENT INCREASE
dc.subjectIMMUNOREACTIVITY
dc.subjectSYNAPTOSOMES
dc.subjectANTIOXIDANT
dc.subjectMONOAMINES
dc.subjectHYPOXIA
dc.subjectACID
dc.titleComprehensive Chemical Profiling and Multidirectional Biological Investigation of Two Wild Anthemis Species (Anthemis tinctoria var. Pallida and A. cretica subsp. tenuiloba): Focus on Neuroprotective Effects
dc.typearticle
dspace.entity.typePublication
local.avesis.idad1034b6-97c6-48df-ac92-e48124e0918f
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber2582
local.journal.numberofpages25
local.journal.quartileQ2
oaire.citation.issue14
oaire.citation.titleMOLECULES
oaire.citation.volume24
relation.isAuthorOfPublication3e59035c-d7b1-4887-b78c-2a9bc207de05
relation.isAuthorOfPublication.latestForDiscovery3e59035c-d7b1-4887-b78c-2a9bc207de05

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