Publication:
Anti-inflammatory effects of montelukast on smoke-induced lung injury in rats

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dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsBasyigit, Ilknur; Sahin, Murat; Sahin, Deniz; Yildiz, Fusun; Boyaci, Hasim; Sirvanci, Serap; Ercan, Feriha
dc.date.accessioned2022-03-14T08:27:24Z
dc.date.available2022-03-14T08:27:24Z
dc.date.issued2010
dc.description.abstractAim: To evaluate the effects of montelukast in smoke-induced lung injury. Methods: 28 Wistar-Albino rats were enrolled into 4 groups with 7 rats per group. The healthy control group was exposed to fresh air while all rats in the 3 experimental groups were exposed to cigarette smoke for 20 weeks for 2 hours per day. After histopathological verification of smoke induced lung injury, montelukast (0.1 mg/kg) dissolved in Na(2)CO(3) was given in one group (MON), Na(2)CO(3) only was given in another group (MON control) and placebo was injected in the third group (COPD control) intraperitoneally for 21 days. At the end of this period blood samples were obtained for serum TNF-alpha assessment and light and electron microscopy analyses were performed on the lung tissues of sacrificed rats. Results: Serum TNF-a levels in the MON group were significantly lower than in the MON control and COPD control groups (38.84 +/- 4.9 pg/ml, 77.5 +/- 5.8 pg/ml and 79.2 +/- 6.9 pg/ml respectively, p < 0.05). Furthermore there was no statistically significant difference between the MON group and healthy controls with respect to serum TNF-alpha levels (38.84 +/- 4.9 pg/ml vs. 29.5 +/- 3.6 pg/ml, p > 0.05). Light and electron microscopic evaluation of the lungs demonstrated that the total histopathological damage score of the lung samples was significantly lower in the MON group than in MON controls and COPD controls (5.14 +/- 0.5, 8.4 +/- 0.6 and 8.7 +/- 0.4 respectively, p < 0.05), while there was no significant difference between the MON group and healthy controls (5.1 +/- 0.6 vs 2.3 +/- 0.2, p > 0.05). Conclusion: These findings suggest that montelukast might have a protective effect on smoke-induced lung injury in rats both from a histopathological and inflammatory point of view.
dc.identifier.doi10.1186/2049-6958-5-2-92
dc.identifier.issn1828-695X
dc.identifier.pubmed22958835
dc.identifier.urihttps://hdl.handle.net/11424/241814
dc.identifier.wosWOS:000279761000003
dc.language.isoeng
dc.publisherNOVAMEDIA
dc.relation.ispartofMULTIDISCIPLINARY RESPIRATORY MEDICINE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChronic bronchitis
dc.subjectinflammation
dc.subjectmontelukast
dc.subjectsmoking
dc.subjectOBSTRUCTIVE PULMONARY-DISEASE
dc.subjectKAPPA-B ACTIVATION
dc.subjectSEVERE COPD
dc.subjectASTHMA
dc.subjectMODERATE
dc.subjectINFLAMMATION
dc.subjectMARKERS
dc.titleAnti-inflammatory effects of montelukast on smoke-induced lung injury in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id254c3b29-cc69-4c94-acbc-cd16a834eadb
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages7
oaire.citation.endPage98
oaire.citation.issue2
oaire.citation.startPage92
oaire.citation.titleMULTIDISCIPLINARY RESPIRATORY MEDICINE
oaire.citation.volume5
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication.latestForDiscoveryadc800ed-105c-40c7-a572-6cf3f175be92

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