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Aqueous garlic extract alleviates ischaemia-reperfusion-induced oxidative hepatic injury in rats

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsSener, G; Sehirli, O; Ipci, Y; Ercan, F; Sirvanci, S; Gedik, N; Yegen, BC
dc.date.accessioned2022-03-12T17:19:53Z
dc.date.available2022-03-12T17:19:53Z
dc.date.issued2005
dc.description.abstractThis study was designed to examine the effects of aqueous garlic extract (AGE) on hepatic ischaemia-reperfusion (I/R) injury in rats. For this purpose, Wistar albino rats were subjected to 45min of hepatic ischaemia, followed by a 60-min reperfusion period. AGE (1 mL kg(-1), i.p., corresponding to 500 mg kg(-1)) or saline was administered twice, 15 min before ischaemia and immediately before the reperfusion period. Serum aspartate aminotransferase (AST) and alanine aminotransferase.(ALT) levels were determined to assess liver functions. Liver tissues were taken for the determination of malondialdehyde (MDA) levels, an end product of lipid peroxidation; glutahione (GSP.) levels, a key antioxidant; and myeloperoxidase (MPO) activity, as an indirect index of neutrophil inifiltration Hepatic collagen content, as a fibrosis marker, was also determined. Plasma ALT and AST activities, were elevated in the I/R group as compared with the control group, while these increases significantly decreased by AGE treatment. Hepatic GSH levels, significantly, depressed by I/R were elevated back to control levels in the AGE-treated I/R group. Increases in tissue MDA levels and MPO activity due to I/R injury were reduced back to control levels by AGE treatment. Similarly,, increased hepatic collagen content in the I/R group was reduced to the control level with AGE treatment. Since AGE administration alleviated the I/R-incluced injury of the liver and improved the hepatic and function, it seems likely that AGE, with its antioxidant and oxidant-scavenging properties, may be of potential therapeutic value in protecting the liver against oxidative injury due to ischaemia-reperfusion.
dc.identifier.doi10.1211/0022357055209
dc.identifier.issn0022-3573
dc.identifier.pubmed15639002
dc.identifier.urihttps://hdl.handle.net/11424/228168
dc.identifier.wosWOS:000226187700018
dc.language.isoeng
dc.publisherROYAL PHARMACEUTICAL SOC GREAT BRITAIN
dc.relation.ispartofJOURNAL OF PHARMACY AND PHARMACOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectVASCULAR ENDOTHELIAL-CELLS
dc.subjectGLUTATHIONE
dc.subjectMYELOPEROXIDASE
dc.subjectANTIOXIDANT
dc.subjectMECHANISMS
dc.subjectPREVENTION
dc.subjectPROTECTION
dc.subjectMELATONIN
dc.subjectRADICALS
dc.subjectDAMAGE
dc.titleAqueous garlic extract alleviates ischaemia-reperfusion-induced oxidative hepatic injury in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id9d6b8a3a-faa4-4641-9b27-043d7ba6a26d
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage150
oaire.citation.issue1
oaire.citation.startPage145
oaire.citation.titleJOURNAL OF PHARMACY AND PHARMACOLOGY
oaire.citation.volume57
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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