Publication:
The protective effects of tacrolimus on rat uteri exposed to ischemia-reperfusion injury: a biochemical and histopathologic evaluation

Simple item page
dc.contributor.authorAK, KORAY
dc.contributor.authorsSahin, Sadik; Ozakpinar, Ozlem Bingol; Ak, Koray; Eroglu, Mustafa; Acikel, Merve; Tetik, Sermin; Uras, Fikriye; Cetinel, Sule
dc.date.accessioned2022-03-13T12:45:04Z
dc.date.available2022-03-13T12:45:04Z
dc.date.issued2014
dc.description.abstractObjective: To evaluate the effects of the immunosuppressant tacrolimus as an antioxidant and analyze the histopathologic changes in rat uteri exposed to experimental ischemia-reperfusion (I/R) injury. Design: Experimental study. Setting: Experimental surgery laboratory in a university. Animal(s): Twenty-eight female rats exposed to experimentally induced uterine I/R injury. Intervention(s): Group I: control group; group II: uterine I/R injury-induced group; group III: pre-ischemia tacrolimus group; group IV: post-ischemia tacrolimus group. Main Outcome Measure(s): Uterine tissue malondialdehyde (MDA) level as a marker of lipid peroxidation and glutathione (GSH) level and superoxide dismutase (SOD) and catalase (CAT) activities as markers of tissue antioxidant capacity; histopathologic examination of all uterine rat tissue. Result(s): Following aortic I/R injury, MDA levels were significantly increased whereas GSH levels and CAT and SOD activities were found to be decreased compared with control animals. MDA levels were found to recover prominently after the administration of tacrolimus in both groups III and IV. Administration of tacrolimus improved uterine GSH levels and CAT activity in the tacrolimus-treated groups. Conclusion(s): Our results indicate that tacrolimus reduces oxidative damage in rat uteri exposed to I/R injury induced by distal abdominal aortic occlusion. Histologic evaluation reveals that tacrolimus attenuates the inflammatory response and protects the tissue damage induced by I/R injury. (c) 2014 by American Society for Reproductive Medicine.
dc.identifier.doi10.1016/j.fertnstert.2013.12.044
dc.identifier.eissn1556-5653
dc.identifier.issn0015-0282
dc.identifier.pubmed24502894
dc.identifier.urihttps://hdl.handle.net/11424/237712
dc.identifier.wosWOS:000333805000055
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofFERTILITY AND STERILITY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIschemia-reperfusion injury
dc.subjecttacrolimus
dc.subjectuterus
dc.subjectrat
dc.subjecttransplantation
dc.subjectWARM ISCHEMIA
dc.subjectLIVER-TRANSPLANTATION
dc.subjectISCHEMIA/REPERFUSION INJURY
dc.subjectOXIDATIVE STRESS
dc.subjectFK506
dc.subjectCYCLOSPORINE
dc.subjectGLUTATHIONE
dc.subjectPREGNANCY
dc.subjectCOLD
dc.subjectMECHANISMS
dc.titleThe protective effects of tacrolimus on rat uteri exposed to ischemia-reperfusion injury: a biochemical and histopathologic evaluation
dc.typearticle
dspace.entity.typePublication
local.avesis.id55aaa5ba-ddd7-4240-8007-4147ac039820
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPage1182
oaire.citation.issue4
oaire.citation.startPage1176
oaire.citation.titleFERTILITY AND STERILITY
oaire.citation.volume101
relation.isAuthorOfPublication14a26caf-f6e3-4f46-9cf6-cdbc53973ee6
relation.isAuthorOfPublication.latestForDiscovery14a26caf-f6e3-4f46-9cf6-cdbc53973ee6

Files

Collections

Research Outputs