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Biologically active compounds from two members of the Asteraceae family: Tragopogon dubius Scop. and Tussilago farfara L.

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dc.contributor.authorDOĞAN, AHMET
dc.contributor.authorsUysal, Sengul; Senkardes, Ismail; Mollica, Adriano; Zengin, Gokhan; Bulut, Gizem; Dogan, Ahmet; Glamoclija, Jasmina; Sokovic, Marina; Lobine, Devina; Mahomoodally, Fawzi M.
dc.date.accessioned2022-03-12T22:39:18Z
dc.date.available2022-03-12T22:39:18Z
dc.date.issued2019
dc.description.abstractTragopogon dubius and Tussilago farfara are consumed as vegetables and used in folk medicine to manage common diseases. Herein, the chemical compositions and biological activities of different leaf extracts (ethyl acetate, methanol, and water) of T. dubius and T. farfara were evaluated. The antibacterial, antifungal, and antioxidant abilities of the extracts were tested using different assays including free radical scavenging, reducing power, phosphomolybdenum, and metal chelating assays. Enzyme inhibitory potentials were evaluated against cholinesterases, tyrosinase, alpha-amylase and alpha-glucosidase. Complexes of bioactive compounds (chlorogenic and rosmarinic acid) were docked into the enzymatic cavity of alpha-glucosidase and subjected to molecular dynamic calculation, enzyme conformational stability, and flexibility analysis. T. dubius and T. farfara extracts showed remarkable antioxidant potentials. Ethyl acetate extracts of T. dubius and T. farfara were the most potent inhibitors of acetylcholinesterase and butyrylcholinesterase. T. dubius ethyl acetate extract and T. farfara methanolic extract showed noteworthy activity against alpha-glucosidase. High performance liquid chromatography analysis revealed the abundance of some phenolic compounds including chlorogenic and rosmarinic acids. Ethyl acetate extract of T. dubius showed notable antifungal activity against all strains. Docking studies showed best pose for chlorogenic acid was stabilized by a network of hydrogen bonds with residues Asp1157, Asp1279, whereas rosmarinic acid showed several hydrogen bonds with Asp1157, Asp1420, Asp1526, Lys1460 and Trp1369. This study further validates the use of T. dubius and T. farfara in traditional medicine, as well as act as a stimulus for further studies for future biomedicine development. Communicated by Ramaswamy H. Sarma
dc.identifier.doi10.1080/07391102.2018.1506361
dc.identifier.eissn1538-0254
dc.identifier.issn0739-1102
dc.identifier.pubmed30058457
dc.identifier.urihttps://hdl.handle.net/11424/235801
dc.identifier.wosWOS:000472122100020
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS INC
dc.relation.ispartofJOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectT
dc.subjectdubius
dc.subjectT
dc.subjectfarfara
dc.subjectpolyphenols
dc.subjectantioxidant
dc.subjectenzyme inhibition
dc.subjectin silico studies
dc.subjectFLOWER BUDS
dc.subjectIN-VITRO
dc.subjectANTIOXIDANT ACTIVITY
dc.subjectNATURAL-PRODUCTS
dc.subjectANTIACETYLCHOLINESTERASE ACTIVITIES
dc.subjectNEURODEGENERATIVE DISEASES
dc.subjectPYRROLIZIDINE ALKALOIDS
dc.subjectINHIBITORY-ACTIVITIES
dc.subjectPHENOLIC-COMPOUNDS
dc.subjectOXIDATIVE STRESS
dc.titleBiologically active compounds from two members of the Asteraceae family: Tragopogon dubius Scop. and Tussilago farfara L.
dc.typearticle
dspace.entity.typePublication
local.avesis.idd6daccc3-4c7e-4c06-ad2c-f4c550f449fa
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages13
oaire.citation.endPage3281
oaire.citation.issue12
oaire.citation.startPage3269
oaire.citation.titleJOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
oaire.citation.volume37
relation.isAuthorOfPublication34e928c8-270a-41b3-8311-23fba8b897ed
relation.isAuthorOfPublication.latestForDiscovery34e928c8-270a-41b3-8311-23fba8b897ed

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