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Detection of Mitochondrial DNA Mutations in Nonmuscle Invasive Bladder Cancer

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dc.contributor.authorGÜNEY, AHMET İLTER
dc.contributor.authorsGuney, Ahmet Ilter; Ergec, Deniz Sevinc; Tavukcu, Hasan Huseyin; Koc, Gulsah; Kirac, Deniz; Ulucan, Korkut; Javadova, Dilara; Turkeri, Levent
dc.date.accessioned2022-03-12T18:06:43Z
dc.date.available2022-03-12T18:06:43Z
dc.date.issued2012
dc.description.abstractBackground: Mitochondrial DNA (mtDNA) mutations have been recently described in various tumors; however, data focusing on bladder cancer are scarce. To understand the significance of mtDNA mutations in bladder cancer development, we investigated the mtDNA alterations in bladder cancer cases. Methods: We studied the mtDNA in 38 bladder tumors and 21 microdissected normal bladder tissue samples. Mitochondrial genes ATPase6, CytB, ND1, and D310 region were amplified by polymerase chain reaction and then sequenced. Results: We detected 40 mutations in our patient population. Our findings indicate that G8697A, G14905A, C15452A, and A15607G mutations are frequent in bladder cancers (p < 0.05). In addition, the incidence of A3480G, T4216C, T14798C, and G9055A mutations were higher in patients with bladder tumors. Conclusions: In conclusion, the high incidence of mtDNA mutations in bladder cancer suggests that mitochondria could play an important role in carcinogenesis and mtDNA could be a valuable marker for early bladder cancer diagnosis.
dc.identifier.doi10.1089/gtmb.2011.0227
dc.identifier.issn1945-0265
dc.identifier.pubmed22533676
dc.identifier.urihttps://hdl.handle.net/11424/230945
dc.identifier.wosWOS:000306475100006
dc.language.isoeng
dc.publisherMARY ANN LIEBERT INC
dc.relation.ispartofGENETIC TESTING AND MOLECULAR BIOMARKERS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMONONUCLEOTIDE REPEAT
dc.subjectBREAST-CANCER
dc.subjectTUMORS
dc.subjectGENOME
dc.subjectIDENTIFICATION
dc.subjectPATHWAYS
dc.subjectPROSTATE
dc.subjectTARGET
dc.subjectRISK
dc.titleDetection of Mitochondrial DNA Mutations in Nonmuscle Invasive Bladder Cancer
dc.typearticle
dspace.entity.typePublication
local.avesis.id7eba894e-188e-4d2d-86ba-4b730dba2db6
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPage678
oaire.citation.issue7
oaire.citation.startPage672
oaire.citation.titleGENETIC TESTING AND MOLECULAR BIOMARKERS
oaire.citation.volume16
relation.isAuthorOfPublicationd474fc8a-ae88-487e-b63b-7f506191fb94
relation.isAuthorOfPublication.latestForDiscoveryd474fc8a-ae88-487e-b63b-7f506191fb94

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