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Bifidobacterium animalis subsp. lactis as adjunct to non-surgical periodontal treatment in periodontitis: a randomized controlled clinical trial

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dc.contributor.authorKURU, LEYLA
dc.contributor.authorKADİR, TANJU
dc.contributor.authorKÖSE, KEMAL NACİ
dc.contributor.authorsÖzener H. Ö., KURU L., KADİR T., Kuru B.
dc.date.accessioned2023-02-07T07:55:01Z
dc.date.available2023-02-07T07:55:01Z
dc.date.issued2023-01-01
dc.description.abstract© 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.Objectives: The purpose of this study is to investigate the clinical and microbiological effects of Bifidobacterium animalis subsp. lactis DN-173010 containing yogurt as an adjunct to non-surgical periodontal treatment in periodontitis patients. Materials and methods: This is a prospective randomized controlled clinical study registered with NCT05408364 under clinical trial registration. Thirty periodontitis patients were divided into 2 groups at random. As adjunctive to supra and subgingival instrumentation, the test group consumed Bifidobacterium animalis subsp. lactis DN-173010 containing yogurt while the control group consumed natural yogurt, once daily for 28 days. The plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), and clinical attachment level (CAL) were recorded at baseline, 28th day, and 3rd month. Microbiological analysis was performed using culture method by obtaining subgingival plaque samples from 2 periodontal sites with 4≤PD≤6 mm at the same time points. Results: The inter-group comparisons of PI, GI, and BOP as well as the changes between the measurement time points were statistically significant in favor of the test group. There were no significant differences in terms of PD and CAL changes between the study groups at all times (∆baseline–28 days, ∆baseline–3 months) (p>0.05). The number of patients presenting subgingival Bifidobacterium species was significantly greater in the test group than the control group at the 28th day (p<0.05). Conclusions: The administration of probiotics has shown beneficial effects, albeit limited, on clinical and microbiological outcomes in the management of periodontitis patients. Clinical relevance: Daily consumption of probiotic yogurt may be supportive for supra and subgingival instrumentation.
dc.identifier.citationÖzener H. Ö., KURU L., KADİR T., Kuru B., "Bifidobacterium animalis subsp. lactis as adjunct to non-surgical periodontal treatment in periodontitis: a randomized controlled clinical trial", Clinical Oral Investigations, 2023
dc.identifier.doi10.1007/s00784-023-04870-1
dc.identifier.issn1432-6981
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85147011668&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/285998
dc.language.isoeng
dc.relation.ispartofClinical Oral Investigations
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDiş Hekimliği
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectDentistry
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectDİŞ HEKİMLİĞİ, ORAL CERRAHİ VE TIP
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectDENTISTRY, ORAL SURGERY & MEDICINE
dc.subjectGeneral Dentistry
dc.subjectBifidobacterium
dc.subjectDental scaling
dc.subjectPeriodontitis
dc.subjectProbiotics
dc.subjectRoot planing
dc.titleBifidobacterium animalis subsp. lactis as adjunct to non-surgical periodontal treatment in periodontitis: a randomized controlled clinical trial
dc.typearticle
dspace.entity.typePublication
local.avesis.id72dbfead-d049-4288-9102-77bdae436e66
local.indexed.atPUBMED
local.indexed.atSCOPUS
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