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Ubiquitin proteasomal system is a potential target of the toxic effects of organophosphorus flame retardant triphenyl phosphate

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dc.contributor.authorYILMAZ GÖLER, AYŞE MİNE
dc.contributor.authorsJannuzzı A. T. , Yılmaz Göler A. M. , Alpertunga B.
dc.date.accessioned2022-12-23T08:54:07Z
dc.date.available2022-12-23T08:54:07Z
dc.date.issued2022-11-01
dc.description.abstract© 2022 Elsevier B.V.The consumption of the widely used flame retardant Triphenyl phosphate (TPP) is increasing. It is now frequently detected in the environment and also domestically. Although the possibility of dermal exposure to TPP is quite high, little is known about its potential molecular toxicity mechanisms. In this study, we found that TPP caused cytotoxicity on human skin keratinocytes (HaCaT) and significantly inhibited the proliferation and cell migration in a concentration-dependent manner. Additionally, HaCaT cells were sensitive to TPP-induced apoptosis. Reactive oxygen species production was induced with TPP, which increased the protein carbonylation and lipid peroxidation levels. Moreover, TPP inhibited proteasome activity and increased the accumulation of ubiquitinated proteins. Exposure to TPP significantly increased the HSP90, HSP70, GRP94 and GRP78 protein levels. Overall, our findings indicate that TPP may pose a risk to human health and contribute to the current understanding of the risks of TPP at the molecular level.
dc.identifier.citationJannuzzı A. T. , Yılmaz Göler A. M. , Alpertunga B., "Ubiquitin proteasomal system is a potential target of the toxic effects of organophosphorus flame retardant triphenyl phosphate", Environmental Toxicology and Pharmacology, cilt.96, 2022
dc.identifier.doi10.1016/j.etap.2022.104005
dc.identifier.endpage10
dc.identifier.issn1382-6689
dc.identifier.startpage1
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/dd99a243-8c77-4d93-88ba-2bddca4f26c0/file
dc.identifier.urihttps://hdl.handle.net/11424/283909
dc.identifier.volume96
dc.language.isoeng
dc.relation.ispartofEnvironmental Toxicology and Pharmacology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTemel Eczacılık Bilimleri
dc.subjectEczacılık
dc.subjectMeslek Bilimleri
dc.subjectFarmasötik Toksikoloji
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectBasic Pharmaceutics Sciences
dc.subjectPharmacology and Therapeutics
dc.subjectProfessional Sciences
dc.subjectPharmaceutical Toxicology
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectTemel Bilimler (SCI)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectDoğa Bilimleri Genel
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectÇOK DİSİPLİNLİ BİLİMLER
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectTOKSİKOLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectNatural Sciences (SCI)
dc.subjectLife Sciences (LIFE)
dc.subjectNATURAL SCIENCES, GENERAL
dc.subjectPHARMACOLOGY & TOXICOLOGY
dc.subjectMULTIDISCIPLINARY SCIENCES
dc.subjectPHARMACOLOGY & PHARMACY
dc.subjectTOXICOLOGY
dc.subjectToksikoloji
dc.subjectFarmakoloji
dc.subjectFarmakoloji, Toksikoloji ve Eczacılık (çeşitli)
dc.subjectGenel Farmakoloji, Toksikoloji ve Eczacılık
dc.subjectFarmakoloji (tıbbi)
dc.subjectİlaç Rehberleri
dc.subjectSağlık, Toksikoloji ve Mutajenez
dc.subjectMultidisipliner
dc.subjectFizik Bilimleri
dc.subjectPharmacy
dc.subjectToxicology
dc.subjectPharmacology
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology (medical)
dc.subjectDrug Guides
dc.subjectHealth, Toxicology and Mutagenesis
dc.subjectMultidisciplinary
dc.subjectPhysical Sciences
dc.subjectTriphenyl phosphate
dc.subjectProteasome activity
dc.subjectOxidative stress
dc.subjectHeat shock stress
dc.subjectEndoplasmic reticulum stress
dc.subjectOXIDATIVE STRESS
dc.subjectLIPID-METABOLISM
dc.subjectHAND WIPES
dc.subjectEXPOSURE
dc.subjectINDOOR
dc.subjectDUST
dc.subjectWATER
dc.subjectPLASTICIZERS
dc.subjectINHIBITION
dc.subjectMECHANISMS
dc.titleUbiquitin proteasomal system is a potential target of the toxic effects of organophosphorus flame retardant triphenyl phosphate
dc.typearticle
dspace.entity.typePublication
local.avesis.iddd99a243-8c77-4d93-88ba-2bddca4f26c0
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication8a72311b-9078-47c0-9fd8-bd73292b7739
relation.isAuthorOfPublication.latestForDiscovery8a72311b-9078-47c0-9fd8-bd73292b7739

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