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Beneficial effects of glycocholic acid (GCA) on gut mucosal damage in bile duct ligated rats

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dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsOktar, B. K.; Gülpinar, M. A.; Ercan, F.; Cingi, A.; Alican, I.; Yegen, B. C.
dc.date.accessioned2022-03-15T11:10:25Z
dc.date.available2022-03-15T11:10:25Z
dc.date.issued2001
dc.description.abstractIn order to investigate the effect of bile acids on gastrointestinal inflammations, bile duct ligated rats (BDL) were treated with GCA (25 mM/ml, oral or colonic) or saline I h before ethanol challenge and twice daily for 3 days in the ileitis group, while GCA was given twice daily for 3 days in the colitis group. BDL reduced the macroscopic and microscopic damage scores in the ileitis group compared to sham operated group, while it had no significant effect on ulcer or colitis groups. However, GCA given in BDL group reduced the ulcer index and microscopic damage in colitis group compared to saline-treated groups, but had no effect in ileitis group. Both BDL and GCA administration in BDL group reduced ileitis- or colitis-induced elevations in MPO levels. GCA administration in BDL group inhibited gastric acid output and volume. Our results suggest that oral or colonic administration of primary bile acids may be useful for the treatment of gastrointestinal inflammations.
dc.identifier.doi10.1023/a:1012812616083
dc.identifier.issn0360-3997
dc.identifier.pubmedPMID: 11820458
dc.identifier.urihttps://hdl.handle.net/11424/248680
dc.language.isoeng
dc.relation.ispartofInflammation
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnimals
dc.subjectRats
dc.subjectDisease Models, Animal
dc.subjectColitis
dc.subjectIntestinal Mucosa
dc.subjectPeroxidase
dc.subjectBile Ducts
dc.subjectLigation
dc.subjectEthanol
dc.subjectGastric Acid
dc.subjectBile Acids and Salts
dc.subjectGlycocholic Acid
dc.subjectIleitis
dc.subjectInflammatory Bowel Diseases
dc.subjectPeptic Ulcer
dc.titleBeneficial effects of glycocholic acid (GCA) on gut mucosal damage in bile duct ligated rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id04abb0c5-3f14-40b7-8661-cb847adffc20
local.import.packageSS23
local.import.sourcePubMed
local.indexed.atPUBMED
oaire.citation.endPage318
oaire.citation.startPage311
oaire.citation.titleInflammation
oaire.citation.volume5
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication.latestForDiscoveryadc800ed-105c-40c7-a572-6cf3f175be92

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