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Evaluation of DNA damage in construction-site workers occupationally exposed to welding fumes and solvent-based paints in Turkey

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dc.contributor.authorBECEREN, AYFER
dc.contributor.authorsSardas, Semra; Omurtag, Gulden Z.; Tozan, Ayfer; Gul, Hulya; Beyoglu, Diren
dc.date.accessioned2022-03-12T17:48:25Z
dc.date.available2022-03-12T17:48:25Z
dc.date.issued2010
dc.description.abstractIn this study, the comet assay was used to evaluate whether welding fume and solvent base paint exposure led to DNA damage in construction-site workers in Turkey. The workers (n = 52) were selected according to their exposure in the construction site and controls (n = 26) from the general population, with no history of occupational exposure. The alkaline comet assay, a standard method for assessing genotoxicity, has been applied in peripheral lymphocytes of all subjects. The mean percentages of DNA in tail (%DNA(T)) of each group were evaluated, including the comparisons between smokers in each different group and the duration of exposure. Significant increase in the mean %DNA(T) (p < 0.01) was observed in all exposed subjects (12.34 +/- 2.05) when compared with controls (6.64 +/- 1.43). Also %DNA(T) was significantly high (p < 0.01) in welders (13.59 +/- 1.89) compared with painters (11.10 +/- 1.35). There was a statistical meaningful difference in % DNA(T) between control and exposed smokers. Our findings indicate that exposure to welding fumes and paints induce genotoxic effect in peripheral lymphocytes, indicating a potential health risk for workers. Therefore, to ensure maximum occupational safety, biomonitoring is of great value for assessing the risk for construction workers.
dc.identifier.doi10.1177/0748233710374463
dc.identifier.eissn1477-0393
dc.identifier.issn0748-2337
dc.identifier.pubmed20542926
dc.identifier.urihttps://hdl.handle.net/11424/229951
dc.identifier.wosWOS:000282583100007
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS INC
dc.relation.ispartofTOXICOLOGY AND INDUSTRIAL HEALTH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDNA damage
dc.subjectconstruction site workers
dc.subjectwelding fumes
dc.subjectsolvent-based paints
dc.subjectcomet assay
dc.subjectCOMET ASSAY
dc.subjectSTRAND BREAKAGE
dc.subjectSTAINLESS-STEEL
dc.subjectLUNG-CANCER
dc.subjectCHROMIUM
dc.subjectWELDERS
dc.subjectLYMPHOCYTES
dc.subjectEXPOSURES
dc.subjectMUTAGENICITY
dc.subjectPARTICLES
dc.titleEvaluation of DNA damage in construction-site workers occupationally exposed to welding fumes and solvent-based paints in Turkey
dc.typearticle
dspace.entity.typePublication
local.avesis.id5c1e72a6-6683-42a7-82b9-440946bd0cd9
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage608
oaire.citation.issue9
oaire.citation.startPage601
oaire.citation.titleTOXICOLOGY AND INDUSTRIAL HEALTH
oaire.citation.volume26
relation.isAuthorOfPublication759fae37-2af1-47e6-92f8-545c02df272b
relation.isAuthorOfPublication.latestForDiscovery759fae37-2af1-47e6-92f8-545c02df272b

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