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Effects of moderate aerobic exercise, low-level laser therapy, or their combination on muscles pathology, oxidative stress and irisin levels in the mdx mouse model of Duchenne muscular dystrophy

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dc.contributor.authorÖZBEYLİ, DİLEK
dc.contributor.authorsArikan S., ALACA N., ÖZBEYLİ D., AÇIKEL ELMAS M., ARBAK S., SÜYEN G.
dc.date.accessioned2023-05-02T08:16:05Z
dc.date.available2023-05-02T08:16:05Z
dc.date.issued2022-09-01
dc.description.abstractThis study aimed to investigate how the combined use of low-level laser therapy (LLLT) and exercise, to reduce the possible side effects and/or increase the benefits of exercise, would affect oxidative stress, utrophin, irisin peptide, and skeletal, diaphragmatic, and cardiac muscle pathologies. In our study, 20 mdx mice were divided into four groups. Groups; sedentary and placebo LLLT (SC), sedentary and LLLT (SL), 30-min swimming exercise (Ex), and 30-min swimming exercise and LLLT (ExL). After 8 weeks of swimming exercise, muscle tests, biochemically; oxidative stress index (OSI), utrophin and irisin levels were measured. Skeletal, diaphragmatic and cardiac muscle histopathological scores, skeletal and cardiac muscle myocyte diameters were determined under the light and electron microscope. While only irisin levels were increased in group SL compared to SC, it was determined that OSI, heart muscle histopathological scores decreased and irisin levels increased in both exercise groups (p < 0.05). In addition, in the ExL group, an increase in rotarod and utrophin levels, and a decrease in muscle and diaphragm muscle histopathological scores were observed (p < 0.05). It was determined that the application of swimming exercise in the mdx mouse model increased the irisin level in the skeletal muscle, while reducing the OSI, degeneration in the heart muscle, inflammation and cardiopathy. When LLLT was applied in addition to exercise, muscle strength, skeletal muscle utrophin levels increased, and skeletal and diaphragmatic muscle degeneration and inflammation decreased. In addition, it was determined that only LLLT application increased the level of skeletal muscle irisin.
dc.identifier.citationArikan S., ALACA N., ÖZBEYLİ D., AÇIKEL ELMAS M., ARBAK S., SÜYEN G., "Effects of moderate aerobic exercise, low-level laser therapy, or their combination on muscles pathology, oxidative stress and irisin levels in the mdx mouse model of Duchenne muscular dystrophy", LASERS IN MEDICAL SCIENCE, cilt.37, sa.7, ss.2925-2936, 2022
dc.identifier.doi10.1007/s10103-022-03562-8
dc.identifier.endpage2936
dc.identifier.issn0268-8921
dc.identifier.issue7
dc.identifier.startpage2925
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/35441320/
dc.identifier.urihttps://hdl.handle.net/11424/289035
dc.identifier.volume37
dc.language.isoeng
dc.relation.ispartofLASERS IN MEDICAL SCIENCE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectCerrahi Tıp Bilimleri
dc.subjectBiyomedikal Mühendisliği
dc.subjectMühendislik ve Teknoloji
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectSurgery Medicine Sciences
dc.subjectBiomedical Engineering
dc.subjectEngineering and Technology
dc.subjectMÜHENDİSLİK, BİYOMEDİKAL
dc.subjectMühendislik
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectCERRAHİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectENGINEERING, BIOMEDICAL
dc.subjectENGINEERING
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectSURGERY
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectGeneral Engineering
dc.subjectEngineering (miscellaneous)
dc.subjectBioengineering
dc.subjectSurgery
dc.subjectPhysical Sciences
dc.subjectDuchenne
dc.subjectMdx mice
dc.subjectExercise
dc.subjectLow-level laser therapy
dc.subjectIrisin
dc.subjectMuscle
dc.subjectHeart
dc.subjectRAT SKELETAL-MUSCLE
dc.subjectDEGENERATION
dc.subjectCONTRACTILE
dc.subjectDYSFUNCTION
dc.subjectOXIDASE
dc.subjectMARKERS
dc.subjectMICE
dc.subjectFAT
dc.subjectDuchenne
dc.subjectMdx mice
dc.subjectExercise
dc.subjectLow-level laser therapy
dc.subjectIrisin
dc.subjectMuscle
dc.subjectHeart
dc.titleEffects of moderate aerobic exercise, low-level laser therapy, or their combination on muscles pathology, oxidative stress and irisin levels in the mdx mouse model of Duchenne muscular dystrophy
dc.typearticle
dspace.entity.typePublication
local.avesis.id2ead134d-7714-4b5d-b0ae-4de0a6424176
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication4681bb67-e40b-4cf0-8154-5472237f2325
relation.isAuthorOfPublication.latestForDiscovery4681bb67-e40b-4cf0-8154-5472237f2325

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