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Ventricular and atrial functions assessed byspeckle-trackingechocardiography in patients with human immunodeficiency virus

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dc.contributor.authorÇİNÇİN, AHMET ALTUĞ
dc.contributor.authorsCincin, Altug; Ozben, Beste; Tukenmez Tigen, Elif; Sunbul, Murat; Sayar, Nurten; Gurel, Emre; Tigen, Kursat; Korten, Volkan
dc.date.accessioned2022-03-12T22:39:57Z
dc.date.available2022-03-12T22:39:57Z
dc.date.issued2021
dc.description.abstractPurpose Antiretroviral therapy (ART) has dramatically changed the clinical manifestation of human immunodeficiency virus (HIV) associated cardiomyopathy from severe left ventricular (LV) systolic dysfunction to a pattern of subclinical cardiac dysfunction. The aim of this study was to evaluate by speckle tracking echocardiography (STE) LV, right ventricular (RV), and biatrial functions in HIV-infected patients under different ART combinations. Methods We consecutively included 128 HIV-infected patients (mean age 44.2 +/- 10.1 years, 110 males) and 100 controls (mean age 42.1 +/- 9.4 years, 83 males). Ventricular and atrial functions were assessed by both conventional and STE. Results Although there was not any significant difference in conventional echocardiographic variables, HIV-infected patients had significantly lower LV global longitudinal strain (GLS), RV GLS, left atrial (LA) reservoir and conduit strain, and right atrial conduit strain. HIV patients receiving integrase strand transfer inhibitors and protease inhibitors (PI) had significantly lower LV GLS and LA conduit strain, while patients receiving non-nucleoside reverse transcriptase inhibitors and PI had significantly lower RV GLS than controls. CD4 count at the time of echocardiography was strongly correlated with LV GLS (r= .619,P< .001) and RV GLS (r = .606,P< .001). Conclusion Biventricular and atrial functions are subclinically impaired in HIV-infected patients. ART regimen may also affect myocardial functions.
dc.identifier.doi10.1002/jcu.22921
dc.identifier.eissn1097-0096
dc.identifier.issn0091-2751
dc.identifier.pubmed32954546
dc.identifier.urihttps://hdl.handle.net/11424/235884
dc.identifier.wosWOS:000571195800001
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofJOURNAL OF CLINICAL ULTRASOUND
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjecthuman immunodeficiency virus
dc.subjectspeckle tracking echocardiography
dc.subjectstrain
dc.subjectSPECKLE TRACKING ECHOCARDIOGRAPHY
dc.subjectACTIVE ANTIRETROVIRAL THERAPY
dc.subjectHIV-INFECTED CHILDREN
dc.subjectEUROPEAN ASSOCIATION
dc.subjectGENERAL-POPULATION
dc.subjectAMERICAN SOCIETY
dc.subjectCARDIAC-FUNCTION
dc.subjectHEART-FAILURE
dc.subjectSTRAIN
dc.subjectADULTS
dc.titleVentricular and atrial functions assessed byspeckle-trackingechocardiography in patients with human immunodeficiency virus
dc.typearticle
dspace.entity.typePublication
local.avesis.idf96a39e0-3600-4579-8a99-d1c95dc71a0f
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages10
local.journal.quartileQ4
oaire.citation.endPage350
oaire.citation.issue4
oaire.citation.startPage341
oaire.citation.titleJOURNAL OF CLINICAL ULTRASOUND
oaire.citation.volume49
relation.isAuthorOfPublication54255a29-54c0-43de-8bc5-39d805d1296a
relation.isAuthorOfPublication.latestForDiscovery54255a29-54c0-43de-8bc5-39d805d1296a

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