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Qualitative Fingerprint Analysis and Multidirectional Assessment of Different Crude Extracts and Essential Oil from Wild Artemisia santonicum L.

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dc.contributor.authorŞENKARDEŞ, İSMAİL
dc.contributor.authorsFerrante, Claudio; Zengin, Gokhan; Menghini, Luigi; Diuzheva, Alina; Jeko, Jozsef; Cziaky, Zoltan; Recinella, Lucia; Chiavaroli, Annalisa; Leone, Sheila; Brunetti, Luigi; Lobine, Devina; Senkardes, Ismail; Mahomoodally, Mohamad Fawzi; Orlando, Giustino
dc.date.accessioned2022-03-14T10:18:00Z
dc.date.available2022-03-14T10:18:00Z
dc.date.issued2019-08-07
dc.description.abstractArtemisia species are used as folk medicines in several countries. This work was aimed to shed more light on the effect of methanol, water, ethyl acetate extracts, and essential oil (EO) of A. santonicum on selected enzymes (cholinesterase, tyrosinase alpha-amylase, and alpha-glucosidase) as well of their antioxidant and pharmacological effects. The chemical profile of the essential oil was determined using gas chromatography coupled to mass spectrometry (GC-MS) analysis, while the extracts were chemically characterized by high performance liquid chromatography coupled to mass spectrometry (HPLC-MS). Forty-nine constituents were identified and camphor (36.6%), 1,8-cineole (10.2%), alpha-thujone (10.1%), borneol (4.5%), and beta-thujone (3.6%) were the major components. Overall, 45, 74, and 67 components were identified from the ethyl acetate, methanol, and water extracts, respectively. The EO and extracts showed significant antioxidant properties, in a cell-free model; particularly, methanol and water extracts revealed promising sources of antioxidant compounds. Additionally, we evaluated protective effects of EO and extracts in isolated rat colon tissue challenged with lipopolysaccharide (LPS), as an ex vivo model of colon inflammation, and human colon cancer HCT116 cell line. Particularly, we observed that, among all tested samples, A. santonicum ethyl acetate displayed the best pharmacological profile, being able to blunt LPS-induced levels of all tested biomarkers of inflammation and oxidative stress, including colon nitrites, lactate dehydrogenase, prostaglandin E-2, and serotonin. Additionally, this extract was also able to reduce HCT116 cell viability, thus suggesting potential antiproliferative effects against colon cancer cells. Based on our results, A. santonicum has great potential for developing novel functional agents including pharmaceuticals, cosmeceuticals, and nutraceuticals.
dc.identifier.doi10.3390/pr7080522
dc.identifier.eissn2227-9717
dc.identifier.urihttps://hdl.handle.net/11424/244322
dc.identifier.wosWOS:000483747700071
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofPROCESSES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectArtemisia
dc.subjectessential oil
dc.subjectbioactive compounds
dc.subjectantioxidant
dc.subjectenzyme inhibition
dc.subjectINFLAMMATORY-BOWEL-DISEASE
dc.subjectCHEMICAL-COMPOSITION
dc.subjectANTIOXIDANT ACTIVITY
dc.subjectANTIMICROBIAL ACTIVITY
dc.subjectINHIBITION ACTIVITIES
dc.subjectEXPERIMENTAL COLITIS
dc.subjectALPHA-AMYLASE
dc.subjectAERIAL PARTS
dc.subjectSEROTONIN
dc.subjectFLAVONOIDS
dc.titleQualitative Fingerprint Analysis and Multidirectional Assessment of Different Crude Extracts and Essential Oil from Wild Artemisia santonicum L.
dc.typearticle
dspace.entity.typePublication
local.avesis.id1930ee2e-accb-40d9-97ae-6fc8a1465f29
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.articlenumber522
local.journal.numberofpages16
local.journal.quartileQ2
oaire.citation.issue8
oaire.citation.titlePROCESSES
oaire.citation.volume7
relation.isAuthorOfPublication3e59035c-d7b1-4887-b78c-2a9bc207de05
relation.isAuthorOfPublication.latestForDiscovery3e59035c-d7b1-4887-b78c-2a9bc207de05

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