Publication:
Genomic analysis provides new Insights into biotechnological and industrial potential of parageobacillus thermantarcticus M1

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dc.contributor.authorKASAVİ, CEYDA
dc.contributor.authorTOKSOY ÖNER, EBRU
dc.contributor.authorsYILDIZ S. Y., Finore I., Leone L., Romano I., Lama L., KASAVİ C., Nicolaus B., TOKSOY ÖNER E., Poli A.
dc.date.accessioned2023-07-11T11:26:09Z
dc.date.available2023-07-11T11:26:09Z
dc.date.issued2022-06-01
dc.description.abstractParageobacillus thermantarcticus strain M1 is a Gram-positive, motile, facultative anaerobic, spore forming, and thermophilic bacterium, isolated from geothermal soil of the crater of Mount Melbourne (74 degrees 22 \" S, 164 degrees 40 \" E) during the Italian Antarctic Expedition occurred in Austral summer 1986-1987. Strain M1 demonstrated great biotechnological and industrial potential owing to its ability to produce exopolysaccharides (EPSs), ethanol and thermostable extracellular enzymes, such as an xylanase and a beta-xylosidase, and intracellular ones, such as xylose/glucose isomerase and protease. Furthermore, recent studies revealed its high potential in green chemistry due to its use in residual biomass transformation/valorization and as an appropriate model for microbial astrobiology studies. In the present study, using a systems-based approach, genomic analysis of P. thermantarcticus M1 was carried out to enlighten its functional characteristics. The elucidation of whole-genome organization of this thermophilic cell factory increased our understanding of biological mechanisms and pathways, by providing valuable information on the essential genes related to the biosynthesis of nucleotide sugar precursors, monosaccharide unit assembly, as well as the production of EPSs and ethanol. In addition, gene prediction and genome annotation studies identified genes encoding xylanolytic enzymes that are required for the conversion of lignocellulosic materials to high-value added molecules. Our findings pointed out the significant potential of strain M1 in various biotechnological and industrial applications considering its capacity to produce EPSs, ethanol and thermostable enzymes via the utilization of lignocellulosic waste materials.
dc.identifier.citationYILDIZ S. Y., Finore I., Leone L., Romano I., Lama L., KASAVİ C., Nicolaus B., TOKSOY ÖNER E., Poli A., "Genomic Analysis Provides New Insights Into Biotechnological and Industrial Potential of Parageobacillus thermantarcticus M1", FRONTIERS IN MICROBIOLOGY, cilt.13, 2022
dc.identifier.doi10.3389/fmicb.2022.923038
dc.identifier.issn1664-302X
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218356/pdf/fmicb-13-923038.pdf
dc.identifier.urihttps://hdl.handle.net/11424/291118
dc.identifier.volume13
dc.language.isoeng
dc.relation.ispartofFRONTIERS IN MICROBIOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectLife Sciences
dc.subjectNatural Sciences
dc.subjectMikrobiyoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMICROBIOLOGY
dc.subjectLife Sciences (LIFE)
dc.subjectParageobacillus thermantarcticus
dc.subjectthermophiles
dc.subjectgenome
dc.subjectnext-generation sequencing
dc.subjectexopolysaccharides
dc.subjectBACILLUS-THERMANTARCTICUS
dc.subjectGEOBACILLUS
dc.subjectPURIFICATION
dc.subjectTHERMOGLUCOSIDASIUS
dc.subjectMETABOLISM
dc.subjectSUBTILIS
dc.subjectSEQUENCE
dc.subjectCHOLINE
dc.subjectGENUS
dc.subjectParageobacillus thermantarcticus
dc.subjectthermophiles
dc.subjectgenome
dc.subjectnext-generation sequencing
dc.subjectexopolysaccharides
dc.titleGenomic analysis provides new Insights into biotechnological and industrial potential of parageobacillus thermantarcticus M1
dc.typearticle
dspace.entity.typePublication
local.avesis.id3770301d-98b5-4864-a048-a8a2121d6c39
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication00ca94b2-f593-4763-978e-359ce4df0358
relation.isAuthorOfPublication6118e9e4-a58e-429b-bbec-4f73a3089a2b
relation.isAuthorOfPublication.latestForDiscovery00ca94b2-f593-4763-978e-359ce4df0358

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