Publication: Prognostic significance of necrosis in ampullary carcinomas.
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Date
2024-06-26
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Abstract
Background/aimsNecrosis is an important pathological feature that reflects high malignancy potential in tumors such as hepatocellular carcinoma and renal cell carcinoma. We aimed to elucidate the prognostic impact of necrosis in ampullary carcinomas.Materials and methodsWe reviewed 101 consecutive cases of ampullary carcinoma for tumor necrosis, types of necrosis, macroscopic and microscopic histopathological subtypes, lymphatic-vascular-perineural invasions, and other histopathological parameters.ResultsTumor necrosis was present in 19 (18.8%) cases and was identified as an independent poor prognostic indicator in multivariate survival analysis (p = 0.029).ConclusionThe presence of necrosis in ampullary carcinomas is directly related to vascular and perineural invasion and is a poor prognostic indicator independent of tumor stage. Including the presence of necrosis in the pathology reports of ampullary carcinomas will facilitate risk stratification.
Keywords: Adenocarcinoma, Ampulla of Vater, Carcinoma, Necrosis, Prognosis
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Sağlık Bilimleri, Health Sciences, Klinik Tıp (MED), Clinical Medicine (MED), Adenocarcinoma, Ampulla of Vater, Carcinoma, Necrosis, Prognosis
Citation
Akar K. E., Bagci P., "Prognostic significance of necrosis in ampullary carcinomas.", Irish journal of medical science, 2024