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How should prospective research be designed to legitimately assess the value of urodynamic studies in female urinary incontinence

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dc.contributor.authorTARCAN, TUFAN
dc.contributor.authorsTARCAN T., Finazzi-Agrò E., Kessler T. M., Serati M., Solomon E., Rosier P. F. W. M.
dc.date.accessioned2023-12-13T06:18:43Z
dc.date.available2023-12-13T06:18:43Z
dc.date.issued2023-11-01
dc.description.abstractAims: Since formal evidence demonstrating the value of urodynamic studies (UDS) in functional urology remains elusive, we aimed to consider how best to design robust research for this purpose in female urinary incontinence. Methods: An expert group was convened to debate the following considerations: (a) precedents for formally proving the value of a gold standard diagnostic test, (b) key research principles, (c) defining a study population, (d) selecting endpoints, (e) defining interventional and controls arms, (f) blinding, (g) powering the study, and (h) duration of follow-up. In each case, we considered the strengths and weaknesses of different approaches in terms of scientific validity, ethical acceptability, practicality, and likelihood of bias. Results: We agreed that unlike evaluating therapies, attempting to judge the value of a diagnostic test based on eventual treatment success is conceptually flawed. Nonetheless, we explored the design of a hypothetical randomized controlled trial for this purpose, agreeing that: (1) the study population must sufficiently reflect its real-world counterpart; (2) clinical endpoints should include not only continence status but also other lower urinary tract symptoms and risks of management; (3) participants in the interventional arm should receive individualized management based on their UDS findings; (4) the most scientifically valid approach to the control arm—empiric treatment—is ethically problematic; (5) sufficient statistical power is imperative; and (6) ≥ 2 years\" follow-up is needed to assess the long-term impact of management. Conclusions: Although a perfect protocol does not exist, we recommend careful consideration of our observations when reflecting on past studies or planning new prospective research.
dc.identifier.citationTARCAN T., Finazzi-Agrò E., Kessler T. M., Serati M., Solomon E., Rosier P. F. W. M., "How should prospective research be designed to legitimately assess the value of urodynamic studies in female urinary incontinence?", Neurourology and Urodynamics, cilt.42, sa.8, ss.1639-1646, 2023
dc.identifier.doi10.1002/nau.25273
dc.identifier.endpage1646
dc.identifier.issn0733-2467
dc.identifier.issue8
dc.identifier.startpage1639
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85168880510&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/295590
dc.identifier.volume42
dc.language.isoeng
dc.relation.ispartofNeurourology and Urodynamics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectNefroloji
dc.subjectNöroloji
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectNephrology
dc.subjectNeurology
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectÜROLOJİ VE NEFROLOJİ
dc.subjectKLİNİK NÖROLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectUROLOGY & NEPHROLOGY
dc.subjectCLINICAL NEUROLOGY
dc.subjectNöroloji (klinik)
dc.subjectÜroloji
dc.subjectNeurology (clinical)
dc.subjectUrology
dc.subjectfemale urinary incontinence
dc.subjectprospective research
dc.subjecturodynamics
dc.subjectfemale urinary incontinence
dc.subjectprospective research
dc.subjecturodynamics
dc.titleHow should prospective research be designed to legitimately assess the value of urodynamic studies in female urinary incontinence
dc.typearticle
dspace.entity.typePublication
local.avesis.id905c0fd2-6749-4661-8eb6-99c5040fcf52
local.indexed.atPUBMED
local.indexed.atSCOPUS
local.indexed.atWOS
relation.isAuthorOfPublication879ebbce-00dd-443f-a277-a62048cfd68c
relation.isAuthorOfPublication.latestForDiscovery879ebbce-00dd-443f-a277-a62048cfd68c

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