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Small Steps to the Big Picture for Health-Promoting Applications Through the Use of Chickweed (Stellaria media): In Vitro, In Silico, and Pharmacological Network Approaches

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dc.contributor.authorŞENKARDEŞ, İSMAİL
dc.contributor.authorsCusumano G., Flores G. A., Cetiz M. V., Kurt U., Ak G., Saka E., Aly S. H., Eldahshan O. A., Singab A. N., Zengin G., et al.
dc.date.accessioned2024-10-22T16:24:44Z
dc.date.available2024-10-22T16:24:44Z
dc.date.issued2024-01-01
dc.description.abstractStellaria media L., also called chickweed, is widespread in all parts of the world. In the present study, we investigated the biological properties and chemical profiles of different extracts (ethyl acetate, ethanol, ethanol/water, and water) of S. media. The chemical profiles were examined using UHPLC/MS/MS technique. Regarding the biological properties, antioxidant properties as well as enzyme-inhibiting and cytotoxic effects of the extracts were demonstrated by in vitro methods. To obtain further information about the structure-ability relationship, network pharmacology and molecular docking were also performed. Twelve phenolic compounds were identified in the extracts and most of them were flavonoids (apigenin, kaempferol derivatives, etc.). The water extract showed the best free radical scavenging activity, while the ethanol was the most active in reducing power tests. When inhibiting AChE, the ethyl acetate extract showed the best inhibitory effect. The water extract has a good cytotoxic effect on HepG2 (cell viability: 33.9% at a concentration of 100 g/mL). The analysis, performed using the STRING database, included these 45 cancer-associated targets. The identified hub genes were TP53, CDKN2A, PTEN, KRAS, and HRAS. In molecular docking analysis, acacetin-O-hexoside-O-deoxyhexoside and napigenin-7-O-hexoside exhibit remarkable binding energies with proteins. Consequently, S. media can be potential raw materials for designing functional formulations in the pharmaceutical, nutraceutical, and cosmeceutical industries.
dc.identifier.citationCusumano G., Flores G. A., Cetiz M. V., Kurt U., Ak G., Saka E., Aly S. H., Eldahshan O. A., Singab A. N., Zengin G., et al., "Small Steps to the Big Picture for Health-Promoting Applications Through the Use of Chickweed (Stellaria media): In Vitro, In Silico, and Pharmacological Network Approaches", Food Science and Nutrition, 2024
dc.identifier.doi10.1002/fsn3.4505
dc.identifier.issn2048-7177
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85205540837&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/298115
dc.language.isoeng
dc.relation.ispartofFood Science and Nutrition
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectGıda Mühendisliği
dc.subjectMühendislik ve Teknoloji
dc.subjectAgricultural Sciences
dc.subjectAgriculture
dc.subjectFood Engineering
dc.subjectEngineering and Technology
dc.subjectTarım Ve Çevre Bilimleri (Age)
dc.subjectTarım Bilimleri
dc.subjectGıda Bilimi Ve Teknolojisi
dc.subjectAgriculture & Environment Sciences (Age)
dc.subjectFood Science & Technology
dc.subjectYemek bilimi
dc.subjectYaşam Bilimleri
dc.subjectFood Science
dc.subjectLife Sciences
dc.subjectantioxidant
dc.subjecthealth-promoting
dc.subjectHepG2
dc.subjectStellaria media
dc.titleSmall Steps to the Big Picture for Health-Promoting Applications Through the Use of Chickweed (Stellaria media): In Vitro, In Silico, and Pharmacological Network Approaches
dc.typearticle
dspace.entity.typePublication
local.avesis.id97f5b793-f878-4520-bb4f-7d90db8f2d21
local.indexed.atSCOPUS
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relation.isAuthorOfPublication.latestForDiscoveryccc6a6a9-83c5-40ea-a09d-bfddcba372e0

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