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Clinical features, functional status, and quality of life in patients with late-onset familial Mediterranean fever

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dc.contributor.authorGEZER, HALİSE HANDE
dc.contributor.authorÖZ, NURAN
dc.contributor.authorDURUÖZ, MEHMET TUNCAY
dc.contributor.authorsGursoy D. E., GEZER H. H., ÖZ N., Ozer A., Kasman S. A., DURUÖZ M. T.
dc.date.accessioned2023-08-29T07:50:22Z
dc.date.available2023-08-29T07:50:22Z
dc.date.issued2023-01-01
dc.description.abstractOBJECTIVE: This study aimed to determine the frequency of late-onset familial Mediterranean fever (FMF) and compare the clinical and genetic features, functional status, and health-related quality of life (QoL) of patients with early-onset and late-onset disease. METHODS: Patients with onset of symptoms ≤20 and >20 years of age were classified as early-onset and late-onset FMF, respectively. The clinical characteristics, MEFV gene mutations, and Pras disease severity scores were recorded. Physical disability and QoL were assessed with the health assessment questionnaire (HAQ) and short form 36 (SF-36), respectively. RESULTS: The mean age of 138 patients (104 women and 34 men) was 37.7±12.69 years. The percentages of patients with early-and late-onset FMF were 68.1% and 31.9%, respectively. Female sex, mild disease, arthritis, and sacroiliitis were more common in the late-onset group (p0.05). CONCLUSION: The patients with late-onset FMF had a female predominance, a shorter delay of diagnosis, more frequent arthritis and sacroiliitis, a less frequent homozygous M694V mutation, and a milder disease severity than those with early-on-set disease. Physical function and health-related QoL were similar in early-and late-onset FMF groups.
dc.identifier.citationGursoy D. E., GEZER H. H., ÖZ N., Ozer A., Kasman S. A., DURUÖZ M. T., "Clinical features, functional status, and quality of life in patients with late-onset familial Mediterranean fever", Northern Clinics of Istanbul, cilt.10, sa.4, ss.451-457, 2023
dc.identifier.doi10.14744/nci.2022.76736
dc.identifier.endpage457
dc.identifier.issn2148-4902
dc.identifier.issue4
dc.identifier.startpage451
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85168365948&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/292897
dc.identifier.volume10
dc.relation.ispartofNorthern Clinics of Istanbul
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectMEDICINE, GENERAL & INTERNAL
dc.subjectGenel Tıp
dc.subjectGeneral Medicine
dc.subjectDisease activity
dc.subjectfamilial Mediterranean fever
dc.subjectfunctional status
dc.subjectquality of life
dc.titleClinical features, functional status, and quality of life in patients with late-onset familial Mediterranean fever
dc.typearticle
dspace.entity.typePublication
local.avesis.id873e530b-c15e-4c56-b007-644cb1e8c792
local.indexed.atSCOPUS
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relation.isAuthorOfPublication.latestForDiscovery448ac4c5-d06d-4874-9734-5bc76f6eb2fe

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