Publication:
Are There Any Differences in the Neural and Extracellular Matrix Proteins Density Between Children and Adults with Intrinsic Ureteropelvic Junction Obstruction?

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dc.contributor.authorKAYA, CEVDET
dc.contributor.authorsSahin, Bahadir; Kaya, Cevdet; Talibzade, Farhad; Tanidir, Yiloren; Ercan, Feriha; Demirci, Elif Kervancioglu; Sekerci, Cagri Akin; Akbal, Cem; Simsek, Ferruh
dc.date.accessioned2022-03-14T08:20:51Z
dc.date.available2022-03-14T08:20:51Z
dc.date.issued2017-12-27
dc.description.abstractObjective: To compare changes in connective, neural and muscle tissues, and extracellular matrix in child and adult patients so that we can create a more objective view on the timing of surgery. Materials and Methods: Twenty-six patients, who were operated for ureteropelvic junction (UPJ) obstruction in our clinic between September 2014 and May 2016, were included in the study. For the evaluation of connective tissue, Masson's trichrome staining was used. Muscle, extracellular matrix elements and neural tissue were evaluated with immunohistochemistry using alpha-smooth muscle actin (a-SMA), Tenascin C and S100, respectively. Microscopically, the tissues were scored according to their staining density (0: No staining; 1: Minor; 2: Moderate, 3: Dense). Results: There were 12 children and 14 adults in the study groups. The initial evaluation showed no statistically significant difference between studied tissue types with respect to staining density for all parameters (Masson: p=0.414, a-SMA: p=0.204, Tenascin-C: p=0.264, S100: p=0.534). There was no statistically significant correlation between staining density and renal function percentage of the affected kidney (Masson: r=0.454, p=0.051, alpha-SMA: r=-0.323, p=0.177 -Tenascin-C: r=0.290, p=0.229 -S100: r=-0.080, p=0.744). Conclusion: Our preliminary study showed some structural changes between adult and child patients but there is no statistically significant difference between the groups with respect to staining density scores. These results state that although UPJ obstruction is an ongoing process, there is no correlation between the histological deterioration degree of the UPJ segment and the loss on renal function for both children and adults.
dc.identifier.doi10.4274/jus.1655
dc.identifier.issn2148-9580
dc.identifier.urihttps://hdl.handle.net/11424/241594
dc.identifier.wosWOS:000419241900004
dc.language.isoeng
dc.publisherGALENOS YAYINCILIK
dc.relation.ispartofJOURNAL OF UROLOGICAL SURGERY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectExtracellular matrix
dc.subjectimmunohistochemistry
dc.subjectmuscle tissue
dc.subjectconnective tissue
dc.subjectneural tissue
dc.subjectureteropelvic junction
dc.subjectRENAL-FUNCTION
dc.subjectPYELOPLASTY
dc.subjectHYDRONEPHROSIS
dc.subjectTENASCINS
dc.subjectIMPROVE
dc.titleAre There Any Differences in the Neural and Extracellular Matrix Proteins Density Between Children and Adults with Intrinsic Ureteropelvic Junction Obstruction?
dc.typearticle
dspace.entity.typePublication
local.avesis.idccd18750-f0e8-4be8-862c-548705fd1da9
local.import.packageSS16
local.indexed.atWOS
local.indexed.atTRDIZIN
local.journal.numberofpages6
oaire.citation.endPage182
oaire.citation.issue4
oaire.citation.startPage177
oaire.citation.titleJOURNAL OF UROLOGICAL SURGERY
oaire.citation.volume4
relation.isAuthorOfPublication9dba115d-0d59-46b4-9651-7f0a07c96ecd
relation.isAuthorOfPublication.latestForDiscovery9dba115d-0d59-46b4-9651-7f0a07c96ecd

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