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Prophylactic feeding with immune-enhanced diet ameliorates chemoradiation-induced gastrointestinal injury in rats

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dc.contributor.authorATASOY, BESTE MELEK
dc.contributor.authorsAtasoy, Beste M.; Deniz, Mustafa; Dane, Faysal; Ozen, Zeynep; Turan, Pinar; Ercan, Feriha; Cerikcioglu, Nilguen; Aral, Cenk; Akgun, Zueleyha; Abacioglu, Ufuk; Yegen, Berrak C.
dc.date.accessioned2022-03-12T17:48:54Z
dc.date.available2022-03-12T17:48:54Z
dc.date.issued2010
dc.description.abstractMaterials and methods: Forty-eight Sprague-Dawley rats were divided into control (C, n = 6), irradiation (IR, n = 14), fluoropyrimidine (5-FU, n = 14)-treated, IR + 5-FU (n = 14)-treated groups. Half of each irradiated and/or 5-FU-treated groups were previously fed with IED containing arginine, omega-3-fatty acids and RNA fragments, while the other half were fed a standard rat diet (SD) for eight days before the induction of IR or injection of 5-FU. In IR groups, whole abdominal irradiation (11 Gy) was performed with 6 MV photons. In the 5-FU groups, fluoropyrimidine (100 mg/kg) was administered intraperitoneally 30 min prior to irradiation. All animals were sacrificed on the 4th day of IR or 5-FU injection. Results: Bacterial colony counts in the ceca and mesenteric lymph nodes of IED-fed rats, which have received either 5-FU and/or irradiation were significantly lower than the corresponding SD-fed groups. Morphometric results revealed that gastric, ileal and colonic injuries were less in IED-treated IR or IR + 5-FU + IED groups, as compared to SD-fed groups. However, IED did not alter DNA fragmentation ratios. Conclusion: Prophylactic feeding of IED has a protective effect on chemoradiation-induced gastrointestinal injury, which appears to involve the eradication of bacterial overgrowth.
dc.identifier.doi10.3109/09553002.2010.487026
dc.identifier.eissn1362-3095
dc.identifier.issn0955-3002
dc.identifier.pubmed20653343
dc.identifier.urihttps://hdl.handle.net/11424/230027
dc.identifier.wosWOS:000282519100007
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofINTERNATIONAL JOURNAL OF RADIATION BIOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCAUSES BACTERIAL TRANSLOCATION
dc.subjectPELVIC RADIOTHERAPY
dc.subjectENTERAL NUTRITION
dc.subjectRADIATION ENTERITIS
dc.subjectPROCTITIS SYNDROME
dc.subjectCANCER-PATIENTS
dc.subjectGUT MICROFLORA
dc.subjectBLOOD-FLOW
dc.subjectARGININE
dc.subjectGLUTAMINE
dc.titleProphylactic feeding with immune-enhanced diet ameliorates chemoradiation-induced gastrointestinal injury in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.idd76579be-700d-44cd-8b98-64f9ad6c5997
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages13
oaire.citation.endPage879
oaire.citation.issue10
oaire.citation.startPage867
oaire.citation.titleINTERNATIONAL JOURNAL OF RADIATION BIOLOGY
oaire.citation.volume86
relation.isAuthorOfPublication22ce1b48-93da-4e88-a61e-be24b5e6122a
relation.isAuthorOfPublication.latestForDiscovery22ce1b48-93da-4e88-a61e-be24b5e6122a

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