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Antibiotic prophylaxis in elective thoracic surgery: Cefuroxime versus cefepime

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dc.contributor.authorDURMUŞOĞLU, LÜTFİYE
dc.contributor.authorsTurna, A; Kutlu, CA; Ozalp, T; Karamustafaoglu, A; Maulazimoglu, L; Bedirhan, MA
dc.date.accessioned2022-03-12T17:17:05Z
dc.date.available2022-03-12T17:17:05Z
dc.date.issued2003
dc.description.abstractBackground: Infection is one of the major morbidity factors after thoracic surgery. Although different prophylactic regimens have been used to prevent this complication, the ideal prophylactic agent, dose and duration of administration remain unknown. Methods: All patients included underwent elective lung resection. 102 selected patients consecutively scheduled for major thoracic surgery were enrolled in this study and randomized into either the cefuroxime group (n=50) or the cefepime group (n=52). Results: Twelve pathologic bacterium strains were isolated in the cefepime group, whereas only 5 pathogenic strains were isolated in the cefuroxime group; the difference was statistically significant (p=0.04). Two empyemas (3.8%) in the cefepime group were noted, while the cefuroxime group showed no cases of empyema (p=0.16). Overall infection rate (pneumonia + bronchopneumonia + empyema) were 14.0% and 26.7% in the cefuroxime and the cefepime groups, respectively (p=0.12). Using chest radiography, pulmonary infiltration was found to be more frequent in the cefuroxime group (p=0.002). Conclusion: Cefuroxime as a prophylactic agent in major thoracic surgical operations was marginally more effective than cefepime, and presented an additional cost advantage.
dc.identifier.doi10.1055/s-2003-38991
dc.identifier.eissn1439-1902
dc.identifier.issn0171-6425
dc.identifier.pubmed12730816
dc.identifier.urihttps://hdl.handle.net/11424/227762
dc.identifier.wosWOS:000183038900006
dc.language.isoeng
dc.publisherGEORG THIEME VERLAG KG
dc.relation.ispartofTHORACIC AND CARDIOVASCULAR SURGEON
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectantibiotic prophylaxis
dc.subjectthoracic surgery
dc.subjectinfection
dc.subjectcefuroxime
dc.subjectcefepime
dc.subjectCLINICAL-TRIAL
dc.subjectPLACEBO
dc.titleAntibiotic prophylaxis in elective thoracic surgery: Cefuroxime versus cefepime
dc.typearticle
dspace.entity.typePublication
local.avesis.idf42654ff-fad5-4032-959b-4d350edfa7c4
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages5
oaire.citation.endPage88
oaire.citation.issue2
oaire.citation.startPage84
oaire.citation.titleTHORACIC AND CARDIOVASCULAR SURGEON
oaire.citation.volume51
relation.isAuthorOfPublication05614eca-392c-4f70-a728-f6fec5586b16
relation.isAuthorOfPublication.latestForDiscovery05614eca-392c-4f70-a728-f6fec5586b16

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