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Contribution of M-1 and M-2 muscarinic receptor subtypes to convulsions in fasted mice treated with scopolamine and given food

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dc.contributor.authorAYDIN OMAY, BANU
dc.contributor.authorsBacanak, Merve Saygi; Aydin, Banu; Cabadak, Hulya; Nurten, Asiye; Goren, Mehmet Zafer; Enginar, Nurhan
dc.date.accessioned2022-03-12T22:38:51Z
dc.date.available2022-03-12T22:38:51Z
dc.date.issued2019
dc.description.abstractTreatment of fasted mice and rats with the nonselective muscarinic antagonist, scopolamine or atropine, causes convulsions after food intake. This study evaluated the effect of fasting on the expression of M-1 and M-2 muscarinic receptors in the brain regions, the relationship between receptor expression and seizure stages, and the muscarinic receptor subtype which plays a role in the occurrence of convulsions. Mice were grouped as allowed to eat ad lib (fed) and deprived of food for 24 h (fasted). Fasted animals developed convulsions after being treated with scopolamine (60%) or the selective M-1 receptor antagonist pirenzepine (10 mg/kg; 20% and 60 mg/kg; 70%) and given food. Fasting increased expression of M-1 receptors in the frontal cortex and M-2 receptors in the hippocampus, but produced no change in the expression of both receptors in the amygdaloid complex. Food intake after fasting decreased M-1 receptor expression in the frontal cortex and M-1 and M-2 receptor expression in the hippocampus. Seizure severity was uncorrelated with muscarinic receptor expression in the brain regions. Taken together, these findings provide evidence for the role of M-1 muscarinic receptor antagonism and fasting-induced increases in M-1 and M-2 expression possible underlying mechanism in the occurrence of convulsions in fasted animals.
dc.identifier.doi10.1016/j.bbr.2017.11.018
dc.identifier.eissn1872-7549
dc.identifier.issn0166-4328
dc.identifier.pubmed29158113
dc.identifier.urihttps://hdl.handle.net/11424/235735
dc.identifier.wosWOS:000463130800046
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofBEHAVIOURAL BRAIN RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFasting
dc.subjectConvulsion
dc.subjectM-1 muscarinic receptor expression
dc.subjectM-2 muscarinic receptor expression
dc.subjectScopolamine
dc.subjectPirenzepine
dc.subjectFood intake
dc.subjectACETYLCHOLINE-RELEASE
dc.subjectCHOLINERGIC MODULATION
dc.subjectBASOLATERAL AMYGDALA
dc.subjectCEREBRAL-CORTEX
dc.subjectSEIZURES
dc.subjectBRAIN
dc.subjectM1
dc.subjectLOCALIZATION
dc.subjectEXPRESSION
dc.subjectNUCLEUS
dc.titleContribution of M-1 and M-2 muscarinic receptor subtypes to convulsions in fasted mice treated with scopolamine and given food
dc.typearticle
dspace.entity.typePublication
local.avesis.id578cb647-5f91-46f3-96a6-3858daaf1c56
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
local.journal.quartileQ2
oaire.citation.endPage430
oaire.citation.startPage423
oaire.citation.titleBEHAVIOURAL BRAIN RESEARCH
oaire.citation.volume364
relation.isAuthorOfPublicationaf9e48cc-cef6-4af2-bdb7-5b424aadfc2b
relation.isAuthorOfPublication.latestForDiscoveryaf9e48cc-cef6-4af2-bdb7-5b424aadfc2b

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