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Antioxidant effect of alpha-lipoic acid against ethanol-induced gastric mucosal erosion in rats

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsSehirli, Ozer; Tatlidede, Elif; Yuksel, Meral; Erzik, Can; Cetinel, Sule; Yegen, Berrak C.; Sener, Goksel
dc.date.accessioned2022-03-12T17:34:07Z
dc.date.available2022-03-12T17:34:07Z
dc.date.issued2008
dc.description.abstractBackground/Aims: This investigation elucidates the role of free radicals in ethanol-induced gastric mucosal erosion and the protective effect of lipoic acid. Methods: After overnight fasting, Wistar albino rats were orally treated with 1 ml of absolute ethanol to induce gastric erosion. Lipoic acid (100 mg/kg) was given orally for 3 days before ethanol administration. Mucosal damage was evaluated 1 h after ethanol administration by macroscopic examination and histological analysis. Additional tissue samples were taken for measurement of malondialdehyde, glutathione (GSH), and myelo-per oxidase activity. Production of reactive oxidants and oxidant-induced DNA fragmentation and Na+,K+-ATPase activity were also assayed in the tissue samples. Results: Generation of reactive oxygen species and lipid peroxidation associated with neutrophil infiltration play an important role in the pathogenesis of gastric mucosal damage induced by ethanol. Furthermore, oxidants depleted tissue GSH stores and impaired membrane structure as Na+,K+-ATPase activity was inhibited. On the other hand, lipoic acid treatment reversed all these biochemical indices as well as the histopathological changes induced by ethanol. Conclusion: These data suggest that lipoic acid administration effectively counteracts the deleterious effect of ethanol-induced gastric mucosal injury and attenuates gastric damage through its antioxidant effects. Copyright (C) 2008 S. Karger AG, Basel.
dc.identifier.doi10.1159/000111145
dc.identifier.issn0031-7012
dc.identifier.pubmed18025842
dc.identifier.urihttps://hdl.handle.net/11424/228971
dc.identifier.wosWOS:000251436700013
dc.language.isoeng
dc.publisherKARGER
dc.relation.ispartofPHARMACOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectethanol
dc.subjectgastric mucosal injury
dc.subjectlipoic acid
dc.subjectlipid peroxidation
dc.subjectSPINAL-CORD-INJURY
dc.subjectLIPID-PEROXIDATION
dc.subjectDIHYDROLIPOIC ACID
dc.subjectISCHEMIA-REPERFUSION
dc.subjectFREE-RADICALS
dc.subjectCELL-DEATH
dc.subjectAPOPTOSIS
dc.subjectDAMAGE
dc.subjectINFLAMMATION
dc.subjectSUPEROXIDE
dc.titleAntioxidant effect of alpha-lipoic acid against ethanol-induced gastric mucosal erosion in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id1cc30bde-a81d-4363-9163-824f32ebb14b
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage180
oaire.citation.issue2
oaire.citation.startPage173
oaire.citation.titlePHARMACOLOGY
oaire.citation.volume81
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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