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Quantitative analysis of ciliary ultrastructure in patients with primary ciliary dyskinesia

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dc.contributor.authorKARADAĞ, BÜLENT TANER
dc.contributor.authorsSirvanci, Serap; Uyan, Z. Seda; Ercan, Feriha; Karadag, Bulent; Ersu, Refika; Karakoc, Fazilet; Dagli, Elif; San, Tangul
dc.date.accessioned2022-03-12T17:33:43Z
dc.date.available2022-03-12T17:33:43Z
dc.date.issued2008
dc.description.abstractThe present study was designed to investigate dynein arm and microtubule defects quantitatively in patients with respiratory disease and to establish the clinical relevance of dynein arm deficiency and microtubule abnormalities. Thirty-four patients with recurrent upper and/or lower respiratory infections were included in the study. Nasal mucosal brushings were fixed in glutaraldehyde and routine electron microscopic procedures were carried out. At least 20 cross-sectioned cilia were examined from each subject. Dynein arm and microtubular abnormalities were quantified and a statistical analysis was performed. Twenty-nine percent of the patients showed dynein arm deficiency and a further 21% had possible deficiency (PD). Microtubule defects in patients with dynein arm deficiency and PD were found to be significantly increased compared to the patients with no dynein arm deficiency. The most prominent defect in the dynein arm deficiency group was a translocation of central and/or peripheral microtubules. The high percentage of translocation defect in this group of patients suggests that these defects are primary, rather than secondary to infection. (C) 2007 Elsevier GmbH. All rights reserved.
dc.identifier.doi10.1016/j.acthis.2007.05.006
dc.identifier.eissn1618-0372
dc.identifier.issn0065-1281
dc.identifier.pubmed17698172
dc.identifier.urihttps://hdl.handle.net/11424/228901
dc.identifier.wosWOS:000253237700005
dc.language.isoeng
dc.publisherELSEVIER GMBH
dc.relation.ispartofACTA HISTOCHEMICA
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectprimary ciliary dyskinesia
dc.subjectcilia
dc.subjectultrastructure
dc.subjectquantitative analysis
dc.subjectBRONCHIAL EPITHELIUM
dc.subjectELECTRON-MICROSCOPY
dc.subjectCHILDREN
dc.subjectMICROTUBULES
dc.subjectDYSFUNCTION
dc.subjectBEAT
dc.titleQuantitative analysis of ciliary ultrastructure in patients with primary ciliary dyskinesia
dc.typearticle
dspace.entity.typePublication
local.avesis.idef27d074-f1df-4abe-8675-9f0d8e1ea9ed
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage41
oaire.citation.issue1
oaire.citation.startPage34
oaire.citation.titleACTA HISTOCHEMICA
oaire.citation.volume110
relation.isAuthorOfPublication218b489d-97ab-49dd-9db6-0c2a732f1999
relation.isAuthorOfPublication.latestForDiscovery218b489d-97ab-49dd-9db6-0c2a732f1999

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