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Resveratrol treatment protects against doxorubicin-induced cardiotoxicity by alleviating oxidative damage

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dc.contributor.authorVELİOĞLU ÖĞÜNÇ, AYLİZ
dc.contributor.authorsTatlidede, Elif; Sehirli, Oezer; Velioglu-Ogunc, Ayliz; Cetinel, Sule; Yegen, Berrak C.; Yarat, Aysen; Suleymanoglu, Selami; Sener, Goeksel
dc.date.accessioned2022-03-12T17:46:45Z
dc.date.available2022-03-12T17:46:45Z
dc.date.issued2009
dc.description.abstractThe possible protective effects of resveratrol (RVT) against cardiotoxicity were investigated in Wistar albino rats treated with saline, saline+doxorubicin (DOX; 20 mg/kg) or RVT (10 mg/kg)+DOX. Blood pressure and heart rate were recorded on the 1st week and on the 7th week, while cardiomyopathy was assessed using transthoracic echocardiography before the rats were decapitated. DOX-induced cardiotoxicity resulted in decreased blood pressure and heart rate, but lactate dehydrogenase, creatine phosphokinase, total cholesterol, triglyceride, aspartate aminotransferase and 8-OHdG levels were increased in plasma. Moreover, DOX caused a significant decrease in plasma total antioxidant capacity along with a reduction in cardiac superoxide dismutase, catalase and Na+,K+-ATPase activities and glutathione contents, while malondialdehyde, myelopreoxidase activity and the generation of reactive oxygen species were increased in the cardiac tissue. On the other hand, RVT markedly ameliorated the severity of cardiac dysfunction, while all oxidant responses were prevented; implicating that RVT may be of therapeutic use in preventing oxidative stress due to DOX toxicity.
dc.identifier.doi10.1080/10715760802673008
dc.identifier.eissn1029-2470
dc.identifier.issn1071-5762
dc.identifier.pubmed19169920
dc.identifier.urihttps://hdl.handle.net/11424/229536
dc.identifier.wosWOS:000264531100001
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofFREE RADICAL RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDoxorubicin
dc.subjecttoxicity
dc.subjectresveratrol
dc.subjectfree radical
dc.subjectADRIAMYCIN-INDUCED CARDIOTOXICITY
dc.subjectINDUCED HEART-FAILURE
dc.subjectRED WINE
dc.subjectNITRIC-OXIDE
dc.subjectINDUCED CARDIOMYOPATHY
dc.subjectMOLECULAR-MECHANISM
dc.subjectANTIOXIDANT ENZYMES
dc.subjectLIPID-PEROXIDATION
dc.subjectCARDIAC TOXICITY
dc.subjectRATS
dc.titleResveratrol treatment protects against doxorubicin-induced cardiotoxicity by alleviating oxidative damage
dc.typearticle
dspace.entity.typePublication
local.avesis.ide1fa678e-6c4a-41b7-ad10-53dd2300c398
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumberPII 908147160
local.journal.numberofpages11
oaire.citation.endPage205
oaire.citation.issue3
oaire.citation.startPage195
oaire.citation.titleFREE RADICAL RESEARCH
oaire.citation.volume43
relation.isAuthorOfPublication13300bf6-ba96-4f87-9868-b0d2c86f572a
relation.isAuthorOfPublication.latestForDiscovery13300bf6-ba96-4f87-9868-b0d2c86f572a

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