Publication:
Safety and efficacy of trifluridine/tipiracil in previously treated metastatic colorectal cancer: PRECONNECT Turkey

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dc.contributor.authorDANE, FAYSAL
dc.contributor.authorsÖZET A., DANE F., Aykan N. F. , YALÇIN Ş., EVRENSEL T., ÖZKAN M., Karabulut B., Ormeci M. N. , Atasev O., Vidot L., et al.
dc.date.accessioned2022-10-04T11:04:41Z
dc.date.available2022-10-04T11:04:41Z
dc.date.issued2022-08-01
dc.description.abstractBackground: The efficacy and safety of trifluridine/tipiracil (FTD/TPI) for third-line treatment of metastatic colorectal cancer have been demonstrated. The authors present the Turkish post hoc analysis of the PRECONNECT study. Methods: An international, multicenter, single-arm, open-label, phase IIIb trial evaluating FTD/TPI in patients with >= 2 previous lines of chemotherapy for metastatic colorectal cancer was conducted. The primary end point was safety. Results: In this Turkish cohort (n = 100; eight centers), the most frequent treatment-emergent adverse event was neutropenia (48%). Median progression-free survival was 3.0 months; disease control rate was 36%; quality of life remained stable. Conclusion: Outcomes with FTD/TPI in Turkey are consistent with previous studies and confirm the efficacy and safety of FTD/TPI treatment in the third-line setting.
dc.identifier.citationÖZET A., DANE F., Aykan N. F. , YALÇIN Ş., EVRENSEL T., ÖZKAN M., Karabulut B., Ormeci M. N. , Atasev O., Vidot L., et al., "Safety and efficacy of trifluridine/tipiracil in previously treated metastatic colorectal cancer: PRECONNECT Turkey", FUTURE ONCOLOGY, 2022
dc.identifier.doi10.2217/fon-2022-0455
dc.identifier.issn1479-6694
dc.identifier.urihttps://hdl.handle.net/11424/282072
dc.language.isoeng
dc.relation.ispartofFUTURE ONCOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectOnkoloji
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectOncology
dc.subjectHealth Sciences
dc.subjectONKOLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectONCOLOGY
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.titleSafety and efficacy of trifluridine/tipiracil in previously treated metastatic colorectal cancer: PRECONNECT Turkey
dc.typeconferenceObject
dspace.entity.typePublication
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local.indexed.atWOS
local.indexed.atPUBMED
relation.isAuthorOfPublication059ce50a-8d16-4fc6-a86c-85c9baa19a5c
relation.isAuthorOfPublication.latestForDiscovery059ce50a-8d16-4fc6-a86c-85c9baa19a5c

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